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dc.contributor.authorSung, Yun Juen
dc.contributor.authorde Las Fuentes, Lisaen
dc.contributor.authorWinkler, Thomas Wen
dc.contributor.authorChasman, Daniel Ien
dc.contributor.authorBentley, Amy Ren
dc.contributor.authorKraja, Aldi Ten
dc.contributor.authorNtalla, Ioannaen
dc.contributor.authorWarren, Helen Ren
dc.contributor.authorGuo, Xiuqingen
dc.contributor.authorSchwander, Karenen
dc.contributor.authorManning, Alisa Ken
dc.contributor.authorBrown, Michael Ren
dc.contributor.authorAschard, Huguesen
dc.contributor.authorFeitosa, Mary Fen
dc.contributor.authorFranceschini, Noraen
dc.contributor.authorLu, Yingchangen
dc.contributor.authorCheng, Ching-Yuen
dc.contributor.authorSim, Xuelingen
dc.contributor.authorVojinovic, Dinaen
dc.contributor.authorMarten, Jonathanen
dc.contributor.authorMusani, Solomon Ken
dc.contributor.authorKilpeläinen, Tuomas Oen
dc.contributor.authorRichard, Melissa Aen
dc.contributor.authorAslibekyan, Stellaen
dc.contributor.authorBartz, Traci Men
dc.contributor.authorDorajoo, Rajkumaren
dc.contributor.authorLi, Changweien
dc.contributor.authorLiu, Yongmeien
dc.contributor.authorRankinen, Tuomoen
dc.contributor.authorSmith, Albert Vernonen
dc.contributor.authorTajuddin, Salman Men
dc.contributor.authorTayo, Bamidele Oen
dc.contributor.authorZhao, Weien
dc.contributor.authorZhou, Yanhuaen
dc.contributor.authorMatoba, Nanaen
dc.contributor.authorSofer, Tamaren
dc.contributor.authorAlver, Marisen
dc.contributor.authorAmini, Marzyehen
dc.contributor.authorBoissel, Mathildeen
dc.contributor.authorChai, Jin Fangen
dc.contributor.authorChen, Xuen
dc.contributor.authorDivers, Jasminen
dc.contributor.authorGandin, Ilariaen
dc.contributor.authorGao, Chuanen
dc.contributor.authorGiulianini, Francoen
dc.contributor.authorGoel, Anujen
dc.contributor.authorHarris, Sarah Een
dc.contributor.authorHartwig, Fernando Pen
dc.contributor.authorHe, Meianen
dc.contributor.authorHorimoto, Andrea RVRen
dc.contributor.authorHsu, Fang-Chien
dc.contributor.authorJackson, Anne Uen
dc.contributor.authorKammerer, Candace Men
dc.contributor.authorKasturiratne, Anuradhanien
dc.contributor.authorKomulainen, Pirjoen
dc.contributor.authorKühnel, Brigitteen
dc.contributor.authorLeander, Karinen
dc.contributor.authorLee, Wen-Janeen
dc.contributor.authorLin, Keng-Hungen
dc.contributor.authorLuan, Jian'anen
dc.contributor.authorLyytikäinen, Leo-Pekkaen
dc.contributor.authorMcKenzie, Colin Aen
dc.contributor.authorNelson, Christopher Pen
dc.contributor.authorNoordam, Raymonden
dc.contributor.authorScott, Robert Aen
dc.contributor.authorSheu, Wayne HHen
dc.contributor.authorStančáková, Alenaen
dc.contributor.authorTakeuchi, Fumihikoen
dc.contributor.authorvan der Most, Peter Jen
dc.contributor.authorVarga, Tibor Ven
dc.contributor.authorWaken, Robert Jen
dc.contributor.authorWang, Hemingen
dc.contributor.authorWang, Yajuanen
dc.contributor.authorWare, Erin Ben
dc.contributor.authorWeiss, Stefanen
dc.contributor.authorWen, Wanqingen
dc.contributor.authorYanek, Lisa Ren
dc.contributor.authorZhang, Weihuaen
dc.contributor.authorZhao, Jing Huaen
dc.contributor.authorAfaq, Saimaen
dc.contributor.authorAlfred, Tamunoen
dc.contributor.authorAmin, Najafen
dc.contributor.authorArking, Dan Een
dc.contributor.authorAung, Tinen
dc.contributor.authorBarr, R Grahamen
dc.contributor.authorBielak, Lawrence Fen
dc.contributor.authorBoerwinkle, Ericen
dc.contributor.authorBottinger, Erwin Pen
dc.contributor.authorBraund, Peter Sen
dc.contributor.authorBrody, Jennifer Aen
dc.contributor.authorBroeckel, Ulrichen
dc.contributor.authorCade, Brianen
dc.contributor.authorCampbell, Archieen
dc.contributor.authorCanouil, Mickaëlen
dc.contributor.authorChakravarti, Aravindaen
dc.contributor.authorCocca, Massimilianoen
dc.contributor.authorCollins, Francis Sen
dc.contributor.authorConnell, John Men
dc.contributor.authorde Mutsert, Renéeen
dc.contributor.authorde Silva, H Janakaen
dc.contributor.authorDörr, Marcusen
dc.contributor.authorDuan, Qingen
dc.contributor.authorEaton, Charles Ben
dc.contributor.authorEhret, Georgen
dc.contributor.authorEvangelou, Evangelosen
dc.contributor.authorFaul, Jessica Den
dc.contributor.authorForouhi, Nitaen
dc.contributor.authorFranco, Oscar Hen
dc.contributor.authorFriedlander, Yechielen
dc.contributor.authorGao, Heen
dc.contributor.authorGigante, Brunaen
dc.contributor.authorGu, C Charlesen
dc.contributor.authorGupta, Preetien
dc.contributor.authorHagenaars, Saskia Pen
dc.contributor.authorHarris, Tamara Ben
dc.contributor.authorHe, Jiangen
dc.contributor.authorHeikkinen, Samien
dc.contributor.authorHeng, Chew-Kiaten
dc.contributor.authorHofman, Alberten
dc.contributor.authorHoward, Barbara Ven
dc.contributor.authorHunt, Steven Cen
dc.contributor.authorIrvin, Marguerite Ren
dc.contributor.authorJia, Yuchengen
dc.contributor.authorKatsuya, Tomohiroen
dc.contributor.authorKaufman, Joelen
dc.contributor.authorKerrison, Nicola Den
dc.contributor.authorKhor, Chiea Chuenen
dc.contributor.authorKoh, Woon-Puayen
dc.contributor.authorKoistinen, Heikki Aen
dc.contributor.authorKooperberg, Charles Ben
dc.contributor.authorKrieger, Jose Een
dc.contributor.authorKubo, Michiakien
dc.contributor.authorKutalik, Zoltanen
dc.contributor.authorKuusisto, Johannaen
dc.contributor.authorLakka, Timo Aen
dc.contributor.authorLangefeld, Carl Den
dc.contributor.authorLangenberg, Claudiaen
dc.contributor.authorLauner, Lenore Jen
dc.contributor.authorLee, Joseph Hen
dc.contributor.authorLehne, Benjaminen
dc.contributor.authorLevy, Danielen
dc.contributor.authorLewis, Cora Een
dc.contributor.authorLi, Yizeen
dc.contributor.authorLifelines Cohort Study,en
dc.contributor.authorLim, Sing Huien
dc.contributor.authorLiu, Ching-Tien
dc.contributor.authorLiu, Jianjunen
dc.contributor.authorLiu, Jingminen
dc.contributor.authorLiu, Yehengen
dc.contributor.authorLoh, Marieen
dc.contributor.authorLohman, Kurt Ken
dc.contributor.authorLouie, Tinen
dc.contributor.authorMägi, Reediken
dc.contributor.authorMatsuda, Koichien
dc.contributor.authorMeitinger, Thomasen
dc.contributor.authorMetspalu, Andresen
dc.contributor.authorMilani, Lilien
dc.contributor.authorMomozawa, Yukihideen
dc.contributor.authorMosley, Thomas Hen
dc.contributor.authorNalls, Mike Aen
dc.contributor.authorNasri, Ubaydahen
dc.contributor.authorO'Connell, Jeff Ren
dc.contributor.authorOgunniyi, Adesolaen
dc.contributor.authorPalmas, Walter Ren
dc.contributor.authorPalmer, Nicholette Den
dc.contributor.authorPankow, James Sen
dc.contributor.authorPedersen, Nancy Len
dc.contributor.authorPeters, Annetteen
dc.contributor.authorPeyser, Patricia Aen
dc.contributor.authorPolasek, Ozrenen
dc.contributor.authorPorteous, Daviden
dc.contributor.authorRaitakari, Olli Ten
dc.contributor.authorRenström, Fridaen
dc.contributor.authorRice, Treva Ken
dc.contributor.authorRidker, Paul Men
dc.contributor.authorRobino, Antoniettaen
dc.contributor.authorRobinson, Jennifer Gen
dc.contributor.authorRose, Lynda Men
dc.contributor.authorRudan, Igoren
dc.contributor.authorSabanayagam, Charumathien
dc.contributor.authorSalako, Babatunde Len
dc.contributor.authorSandow, Kevinen
dc.contributor.authorSchmidt, Carsten Oen
dc.contributor.authorSchreiner, Pamela Jen
dc.contributor.authorScott, William Ren
dc.contributor.authorSever, Peteren
dc.contributor.authorSims, Marioen
dc.contributor.authorSitlani, Colleen Men
dc.contributor.authorSmith, Blair Hen
dc.contributor.authorSmith, Jennifer Aen
dc.contributor.authorSnieder, Harolden
dc.contributor.authorStarr, John Men
dc.contributor.authorStrauch, Konstantinen
dc.contributor.authorTang, Huaen
dc.contributor.authorTaylor, Kent Den
dc.contributor.authorTeo, Yik Yingen
dc.contributor.authorTham, Yih Chungen
dc.contributor.authorUitterlinden, André Gen
dc.contributor.authorWaldenberger, Melanieen
dc.contributor.authorWang, Lihuaen
dc.contributor.authorWang, Ya Xingen
dc.contributor.authorWei, Wen Binen
dc.contributor.authorWilson, Gregoryen
dc.contributor.authorWojczynski, Mary Ken
dc.contributor.authorXiang, Yong-Bingen
dc.contributor.authorYao, Jieen
dc.contributor.authorYuan, Jian-Minen
dc.contributor.authorZonderman, Alan Ben
dc.contributor.authorBecker, Diane Men
dc.contributor.authorBoehnke, Michaelen
dc.contributor.authorBowden, Donald Wen
dc.contributor.authorChambers, John Cen
dc.contributor.authorChen, Yii-Der Idaen
dc.contributor.authorWeir, David Ren
dc.contributor.authorde Faire, Ulfen
dc.contributor.authorDeary, Ian Jen
dc.contributor.authorEsko, Tõnuen
dc.contributor.authorFarrall, Martinen
dc.contributor.authorForrester, Terrenceen
dc.contributor.authorFreedman, Barry Ien
dc.contributor.authorFroguel, Philippeen
dc.contributor.authorGasparini, Paoloen
dc.contributor.authorGieger, Christianen
dc.contributor.authorHorta, Bernardo Lessaen
dc.contributor.authorHung, Yi-Jenen
dc.contributor.authorJonas, Jost Brunoen
dc.contributor.authorKato, Norihiroen
dc.contributor.authorKooner, Jaspal Sen
dc.contributor.authorLaakso, Markkuen
dc.contributor.authorLehtimäki, Terhoen
dc.contributor.authorLiang, Kae-Woeien
dc.contributor.authorMagnusson, Patrik KEen
dc.contributor.authorOldehinkel, Albertine Jen
dc.contributor.authorPereira, Alexandre Cen
dc.contributor.authorPerls, Thomasen
dc.contributor.authorRauramaa, Raineren
dc.contributor.authorRedline, Susanen
dc.contributor.authorRettig, Raineren
dc.contributor.authorSamani, Nilesh Jen
dc.contributor.authorScott, Jamesen
dc.contributor.authorShu, Xiao-Ouen
dc.contributor.authorvan der Harst, Pimen
dc.contributor.authorWagenknecht, Lynne Een
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorWatkins, Hughen
dc.contributor.authorWickremasinghe, Ananda Ren
dc.contributor.authorWu, Tangchunen
dc.contributor.authorKamatani, Yoichiroen
dc.contributor.authorLaurie, Cathy Cen
dc.contributor.authorBouchard, Claudeen
dc.contributor.authorCooper, Richard Sen
dc.contributor.authorEvans, Michele Ken
dc.contributor.authorGudnason, Vilmunduren
dc.contributor.authorHixson, Jamesen
dc.contributor.authorKardia, Sharon LRen
dc.contributor.authorKritchevsky, Stephen Ben
dc.contributor.authorPsaty, Bruce Men
dc.contributor.authorvan Dam, Rob Men
dc.contributor.authorArnett, Donna Ken
dc.contributor.authorMook-Kanamori, Dennis Oen
dc.contributor.authorFornage, Myriamen
dc.contributor.authorFox, Ervin Ren
dc.contributor.authorHayward, Carolineen
dc.contributor.authorvan Duijn, Cornelia Men
dc.contributor.authorTai, E Shyongen
dc.contributor.authorWong, Tien Yinen
dc.contributor.authorLoos, Ruth JFen
dc.contributor.authorReiner, Alex Pen
dc.contributor.authorRotimi, Charles Nen
dc.contributor.authorBierut, Laura Jen
dc.contributor.authorZhu, Xiaofengen
dc.contributor.authorCupples, L Adrienneen
dc.contributor.authorProvince, Michael Aen
dc.contributor.authorRotter, Jerome Ien
dc.contributor.authorFranks, Paul Wen
dc.contributor.authorRice, Kennethen
dc.contributor.authorElliott, Paulen
dc.contributor.authorCaulfield, Mark Jen
dc.contributor.authorGauderman, W Jamesen
dc.contributor.authorMunroe, Patricia Ben
dc.contributor.authorRao, Dabeeru Cen
dc.contributor.authorMorrison, Alanna Cen
dc.date.accessioned2019-08-22T23:31:06Z
dc.date.available2019-08-22T23:31:06Z
dc.date.issued2019-08-01en
dc.identifier.issn0964-6906
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/296157
dc.description.abstractElevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene-smoking interaction analysis and 38 were newly identified (P < 5 × 10-8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.
dc.description.sponsorshipU.S. National Heart, Lung, and Blood Institute (NHLBI) (K25HL121091 to Y.J.S.); National Institutes of Health (R01HL118305).
dc.languageengen
dc.publisherOxford University Press
dc.rightsAll rights reserved
dc.rights.uri
dc.titleA multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.en
dc.typeArticle
prism.endingPage2633
prism.issueIdentifier15en
prism.publicationDate2019en
prism.publicationNameHuman Molecular Geneticsen
prism.startingPage2615
prism.volume28en
dc.identifier.doi10.17863/CAM.43206
dcterms.dateAccepted2019-03-26en
rioxxterms.versionofrecord10.1093/hmg/ddz070en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-08-01en
dc.contributor.orcidMarten, Jonathan [0000-0001-6916-2014]
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidZhao, Jing Hua [0000-0003-4930-3582]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1460-2083
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N003284/1)
pubs.funder-project-idQUEEN MARY UNIVERSITY OF LONDON (FB MRC) (MC_PC_14089)
cam.issuedOnline2019-04-10en
cam.orpheus.successThu Jan 30 10:40:02 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-04-10


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