When Bio Meets Technology: Biohybrid Neural Interfaces.
Rochford, Amy E
Curto, Vincenzo F
Advanced materials (Deerfield Beach, Fla.)
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Rochford, A. E., Carnicer-Lombarte, A., Curto, V. F., Malliaras, G., & Barone, D. (2020). When Bio Meets Technology: Biohybrid Neural Interfaces.. Advanced materials (Deerfield Beach, Fla.), 32 (15), e1903182. https://doi.org/10.1002/adma.201903182
The development of electronics capable of interfacing with the nervous system is a rapidly advancing field with applications in basic science and clinical translation. Devices containing arrays of electrodes can be used in the study of cells grown in culture or can be implanted into damaged or dysfunctional tissue to restore normal function. While devices are typically designed and used exclusively for one of these two purposes, there have been increasing efforts in developing implantable electrode arrays capable of housing cultured cells, referred to as biohybrid implants. Once implanted, the cells within these implants integrate into the tissue, serving as a mediator of the electrode-tissue interface. This biological component offers unique advantages to these implant designs, providing better tissue integration and potentially long-term stability. In this progress report we provide an overview of current research into biohybrid devices, as well as the historical background that led to their development. We divide progress in biohybrid devices based on the host anatomical location for which they are designed (CNS, PNS, or special senses). Finally, we provide an overview of key challenges of this technology and discuss potential future research directions.
Neurons, Animals, Humans, Cochlear Implantation, Stem Cell Transplantation, Microarray Analysis, Tissue Engineering, Microfluidics, Electrodes, Implanted, Regenerative Medicine
The authors acknowledge funding from EPSRC (EP/S009000/1 and DTP program), European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No. 732032 (BrainCom) (G.G.M.) and from the King Abdullah University of Science and Technology (KAUST) Office of sponsored Research (OSR) under award No. OSR‑2016‑CRG5‑3003.
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (732032)
King Abdullah University of Science and Technology (KAUST) (OSR-2016-CRG5-3003.2)
External DOI: https://doi.org/10.1002/adma.201903182
This record's URL: https://www.repository.cam.ac.uk/handle/1810/296237