Mucosal IgG in inflammatory bowel disease - a question of (sub)class?
Taylor & Francis
MetadataShow full item record
Castro-Dopico, T., & Clatworthy, M. (2020). Mucosal IgG in inflammatory bowel disease - a question of (sub)class?. Gut microbes, 12 (1), 1-9. https://doi.org/10.1080/19490976.2019.1651596
Immunoglobulins form a cornerstone of mucosal immunity. In the gastrointestinal tract, secretory IgA and IgM bind to commensal microorganisms within the intestinal lumen to prevent them from breaching the intestinal epithelium – a process known as immune exclusion. In recent years, there has been renewed interest in the role of IgG in intestinal immunity, driven in part by a genetic association of an affinity-lowering variant of an IgG receptor, FcγRIIA, with protection from ulcerative colitis (UC), a subclass of inflammatory bowel disease (IBD). We recently demonstrated a role for IgG and FcγR signalling in driving pathogenic IL-1β production by colonic mononuclear phagocytes and the subsequent induction of a local type 17 response in UC. Here, we discuss the potential relevance of our observations to the other major subclass of IBD – Crohn’s disease (CD) – where the genetic association with FCGR variants is less robust and consider how this may impact therapeutic interventions in these disease subsets.
Department of Health (via National Institute for Health Research (NIHR)) (NIHR BTRU-2014-10027)
External DOI: https://doi.org/10.1080/19490976.2019.1651596
This record's URL: https://www.repository.cam.ac.uk/handle/1810/296286
All rights reserved