Repository logo
 

European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND).

Published version
Peer-reviewed

Type

Article

Change log

Authors

Düzel, Emrah 
Acosta-Cabronero, Julio 
Berron, David 
Biessels, Geert Jan 
Björkman-Burtscher, Isabella 

Abstract

INTRODUCTION: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. METHODS: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. RESULTS: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. DISCUSSION: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.

Description

Keywords

Alzheimer's disease (AD), Magnetic resonance imaging (MRI), Mild cognitive impairment (MCI), Parkinson's disease (PD), Subjective cognitive decline (SCD), Ultrahigh-field MRI, Vascular dementia

Journal Title

Alzheimers Dement (Amst)

Conference Name

Journal ISSN

2352-8729
2352-8729

Volume Title

11

Publisher

Wiley
Sponsorship
Wellcome Trust (103838/Z/14/Z)
Medical Research Council (MR/N008537/1)
Medical Research Council (MR/M008983/1)