Age-related retinal thickness in Down's syndrome: A high-risk population for dementia.
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Authors
Walpert, Madeleine
Normando, Eduardo M
Annus, Tiina
Jennings, Sally R
Wilson, Liam R
Publication Date
2019-12Journal Title
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN
2352-8729
Publisher
Elsevier
Volume
11
Pages
744-751
Language
eng
Type
Article
This Version
AM
Physical Medium
Electronic-eCollection
Metadata
Show full item recordCitation
Walpert, M., Normando, E. M., Annus, T., Jennings, S. R., Wilson, L. R., Watson, P., Zaman, S., et al. (2019). Age-related retinal thickness in Down's syndrome: A high-risk population for dementia.. Alzheimer's & dementia (Amsterdam, Netherlands), 11 744-751. https://doi.org/10.1016/j.dadm.2019.08.007
Abstract
INTRODUCTION: People with Down’s syndrome (DS) have a high prevalence of early onset Alzheimer’s disease (AD). Early markers of AD pathology identifiable before clinical change are needed for the evaluation of preventative treatments. The retina, an extension of the brain, may provide a non invasive imaging site.
METHODS: Forty nine adults with DS and 36 age matched controls completed retinal nerve fibre layer (RNFL) assessments using optical coherence tomography (OCT). RNFL thickness was analysed in relation to cognitive status and age, and previously acquired cortical thickness and cerebral amyloid (Aβ) binding data in a subgroup.
RESULTS: RNFL thickness was greater in the DS group and did not show age related thinning. RNFL correlated positively with cognitive scores and cortical thickness and was reduced in participants with positive cerebral Aβ binding,
DISCUSSION: Increased RNFL in adults with DS may represent early AD related changes. Thinning was present in those with cerebral Aβ binding, independent of age.
Sponsorship
ARUK
Stevenage Bioscience Catalyst Open Innovation
Funder references
Stevenage Bioscience Catalyst (unknown)
MRC (G1002252)
Embargo Lift Date
2022-09-03
Identifiers
External DOI: https://doi.org/10.1016/j.dadm.2019.08.007
This record's URL: https://www.repository.cam.ac.uk/handle/1810/296368
Rights
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