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dc.contributor.authorFusco, Giulianaen
dc.contributor.authorChen, Serene Wen
dc.contributor.authorWilliamson, Philip TFen
dc.contributor.authorCascella, Robertaen
dc.contributor.authorPerni, Micheleen
dc.contributor.authorJarvis, James Aen
dc.contributor.authorCecchi, Cristinaen
dc.contributor.authorVendruscolo, Micheleen
dc.contributor.authorChiti, Fabrizioen
dc.contributor.authorCremades Casasin, Nuniloen
dc.contributor.authorYing, Limingen
dc.contributor.authorDobson, Christopheren
dc.contributor.authorDe Simone, Alfonsoen
dc.date.accessioned2019-09-10T23:30:31Z
dc.date.available2019-09-10T23:30:31Z
dc.date.issued2017-12-15en
dc.identifier.issn0036-8075
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/296718
dc.description.abstractOligomeric species populated during the aggregation process of α-synuclein have been linked to neuronal impairment in Parkinson's disease and related neurodegenerative disorders. By using solution and solid-state nuclear magnetic resonance techniques in conjunction with other structural methods, we identified the fundamental characteristics that enable toxic α-synuclein oligomers to perturb biological membranes and disrupt cellular function; these include a highly lipophilic element that promotes strong membrane interactions and a structured region that inserts into lipid bilayers and disrupts their integrity. In support of these conclusions, mutations that target the region that promotes strong membrane interactions by α-synuclein oligomers suppressed their toxicity in neuroblastoma cells and primary cortical neurons.
dc.languageengen
dc.rightsAll rights reserved
dc.titleStructural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.en
dc.typeArticle
prism.issueIdentifier6369en
prism.publicationDate2017en
prism.publicationNameScienceen
prism.volume358en
dc.identifier.doi10.17863/CAM.43761
dcterms.dateAccepted2017-11-14en
rioxxterms.versionofrecord10.1126/science.aan6160en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-12-15en
dc.contributor.orcidFusco, Giuliana [0000-0002-3644-9809]
dc.contributor.orcidChen, Serene W [0000-0001-7084-5621]
dc.contributor.orcidWilliamson, Philip TF [0000-0002-0231-8640]
dc.contributor.orcidCascella, Roberta [0000-0001-9856-6843]
dc.contributor.orcidPerni, Michele [0000-0001-7593-8376]
dc.contributor.orcidCecchi, Cristina [0000-0001-8387-7737]
dc.contributor.orcidVendruscolo, Michele [0000-0002-3616-1610]
dc.contributor.orcidChiti, Fabrizio [0000-0002-1330-1289]
dc.contributor.orcidCremades, Nunilo [0000-0002-9138-6687]
dc.contributor.orcidYing, Liming [0000-0001-9752-6292]
dc.contributor.orcidDobson, Christopher [0000-0002-5445-680X]
dc.contributor.orcidDe Simone, Alfonso [0000-0001-8789-9546]
dc.identifier.eissn1095-9203
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2017-12-15en
rioxxterms.freetoread.startdate2018-12-31


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