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dc.contributor.authorSmith, CPen
dc.contributor.authorHarmon, SAen
dc.contributor.authorBarrett, Tristanen
dc.contributor.authorBittencourt, LKen
dc.contributor.authorLaw, YMen
dc.contributor.authorShebel, Hen
dc.contributor.authorAn, JYen
dc.contributor.authorCzarniecki, Men
dc.contributor.authorMehralivand, Sen
dc.contributor.authorCoskun, Men
dc.contributor.authorWood, BJen
dc.contributor.authorPinto, PAen
dc.contributor.authorShih, JHen
dc.contributor.authorChoyke, PLen
dc.contributor.authorTurkbey, Ben
dc.date.accessioned2019-09-11T23:30:56Z
dc.date.available2019-09-11T23:30:56Z
dc.identifier.issn1053-1807
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/296797
dc.description.abstractBackground: The Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) has been in use since 2015; while interreader reproducibility has been studied, there has been a paucity of studies investigating the intrareader reproducibility of PI-RADSv2. Purpose: To evaluate both intra- and interreader reproducibility of PI-RADSv2 in the assessment of intraprostatic lesions using multiparametric magnetic resonance imaging (mpMRI). Study Type: Retrospective. Population/Subjects: In all, 102 consecutive biopsy-naïve patients who underwent prostate MRI and subsequent MR/transrectal ultrasonography (MR/TRUS)-guided biopsy. Field Strength/Sequences: Prostate mpMRI at 3T using endorectal with phased array surface coils (TW MRI, DW MRI with ADC maps and b2000 DW MRI, DCE MRI). Assessment: Previously detected and biopsied lesions were scored by four readers from four different institutions using PI-RADSv2. Readers scored lesions during two readout rounds with a 4-week washout period. Statistical Tests: Kappa (κ) statistics and specific agreement (Po) were calculated to quantify intra- and interreader reproducibility of PI-RADSv2 scoring. Lesion measurement agreement was calculated using the intraclass correlation coefficient (ICC). Results: Overall intrareader reproducibility was moderate to substantial (κ = 0.43–0.67, Po = 0.60–0.77), while overall interreader reproducibility was poor to moderate (κ = 0.24, Po = 46). Readers with more experience showed greater interreader reproducibility than readers with intermediate experience in the whole prostate (P = 0.026) and peripheral zone (P = 0.002). Sequence-specific interreader agreement for all readers was similar to the overall PI-RADSv2 score, with κ = 0.24, 0.24, and 0.23 and Po = 0.47, 0.44, and 0.54 in T2-weighted, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE), respectively. Overall intrareader and interreader ICC for lesion measurement was 0.82 and 0.71, respectively. Data Conclusion: PI-RADSv2 provides moderate intrareader reproducibility, poor interreader reproducibility, and moderate interreader lesion measurement reproducibility. These findings suggest a need for more standardized reader training in prostate MRI. Level of Evidence: 2. Technical Efficacy: Stage 2.
dc.publisherWiley-Blackwell
dc.rightsAll rights reserved
dc.rights.uri
dc.titleIntra- and interreader reproducibility of PI-RADSv2: A multireader studyen
dc.typeArticle
prism.endingPage1703
prism.issueIdentifier6en
prism.publicationNameJMRI: Journal of Magnetic Resonance Imagingen
prism.startingPage1694
prism.volume46en
dc.identifier.doi10.17863/CAM.43841
dcterms.dateAccepted2018-10-09en
rioxxterms.versionofrecord10.1002/jmri.26555en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-10-09en
dc.contributor.orcidBarrett, Tristan [0000-0002-1180-1474]
dc.identifier.eissn1522-2586
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2018-12-21en
rioxxterms.freetoread.startdate2020-06-30


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