Albumin-based hydrogels for regenerative engineering and cell transplantation.
Biotechnology and bioengineering
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Ong Hui Chong, J., Zhao, J., Justin, A., & Markaki, A. (2019). Albumin-based hydrogels for regenerative engineering and cell transplantation.. Biotechnology and bioengineering, 116 (12), 3457-3468. https://doi.org/10.1002/bit.27167
Albumin, the most abundant plasma protein in mammals, is a versatile and easily obtainable biomaterial. It is pH and temperature responsive, dissolvable in high concentrations and gels readily in defined conditions. This versatility, together with its inexpensiveness and biocompatibility, makes albumin an attractive biomaterial for biomedical research and therapeutics. So far, clinical research in albumin has centred mainly on its use as a carrier molecule or nanoparticle to improve drug pharmacokinetics and delivery to target sites. In contrast, research in albumin-based hydrogels is less established albeit growing in interest over recent years. In this mini-review, we report current literature and critically discuss the synthesis, mechanical properties, biological effects and uses, biodegradability and cost of albumin hydrogels as a xeno-free, customisable and transplantable construct for tissue engineering and regenerative medicine.
Animals, Humans, Albumins, Hydrogels, Drug Carriers, Cell Transplantation, Regenerative Medicine, Nanoparticles
EPSRC Isaac Newton Trust Rosetrees Trust
Isaac Newton Trust (18.07i(c))
External DOI: https://doi.org/10.1002/bit.27167
This record's URL: https://www.repository.cam.ac.uk/handle/1810/296868
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