Show simple item record

dc.contributor.authorOng Hui Chong, Johnen
dc.contributor.authorZhao, Junzheen
dc.contributor.authorJustin, Alexanderen
dc.contributor.authorMarkaki, Athinaen
dc.date.accessioned2019-09-16T23:30:34Z
dc.date.available2019-09-16T23:30:34Z
dc.date.issued2019-12en
dc.identifier.issn0006-3592
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/296868
dc.description.abstractAlbumin, the most abundant plasma protein in mammals, is a versatile and easily obtainable biomaterial. It is pH and temperature responsive, dissolvable in high concentrations and gels readily in defined conditions. This versatility, together with its inexpensiveness and biocompatibility, makes albumin an attractive biomaterial for biomedical research and therapeutics. So far, clinical research in albumin has centred mainly on its use as a carrier molecule or nanoparticle to improve drug pharmacokinetics and delivery to target sites. In contrast, research in albumin-based hydrogels is less established albeit growing in interest over recent years. In this mini-review, we report current literature and critically discuss the synthesis, mechanical properties, biological effects and uses, biodegradability and cost of albumin hydrogels as a xeno-free, customisable and transplantable construct for tissue engineering and regenerative medicine.
dc.description.sponsorshipEPSRC Isaac Newton Trust Rosetrees Trust
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAll rights reserved
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectAlbuminsen
dc.subjectHydrogelsen
dc.subjectDrug Carriersen
dc.subjectCell Transplantationen
dc.subjectRegenerative Medicineen
dc.subjectNanoparticlesen
dc.titleAlbumin-based hydrogels for regenerative engineering and cell transplantation.en
dc.typeArticle
prism.endingPage3468
prism.issueIdentifier12en
prism.publicationDate2019en
prism.publicationNameBiotechnology and bioengineeringen
prism.startingPage3457
prism.volume116en
dc.identifier.doi10.17863/CAM.43910
dcterms.dateAccepted2019-09-12en
rioxxterms.versionofrecord10.1002/bit.27167en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-12en
dc.contributor.orcidOng, John [0000-0001-5103-7311]
dc.contributor.orcidZhao, Junzhe [0000-0002-3224-9105]
dc.contributor.orcidMarkaki, Athina [0000-0002-2265-1256]
dc.identifier.eissn1097-0290
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idIsaac Newton Trust (18.07i(c))
pubs.funder-project-idEPSRC (EP/N509620/1)
cam.orpheus.successThu Jan 30 10:39:04 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-12-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record