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dc.contributor.authorGehrung, Marcel
dc.contributor.authorBohndiek, Sarah
dc.contributor.authorBrunker, Joanna
dc.date.accessioned2019-09-16T23:30:39Z
dc.date.available2019-09-16T23:30:39Z
dc.date.issued2019-10
dc.identifier.issn1083-3668
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/296872
dc.description.abstractPhotoacoustic tomography (PAT) is intrinsically sensitive to blood oxygen saturation (sO2) in vivo. However, making accurate sO2 measurements without knowledge of tissue- and instrumentation-related correction factors is extremely challenging. We have developed a low-cost flow phantom to facilitate validation of PAT systems. The phantom is composed of a flow circuit of tubing partially embedded within a tissue-mimicking material, with independent sensors providing online monitoring of the optical absorption spectrum and partial pressure of oxygen in the tube. We first test the flow phantom using two small molecule dyes that are frequently used for photoacoustic imaging: methylene blue and indocyanine green. We then demonstrate the potential of the phantom for evaluating sO2 using chemical oxygenation and deoxygenation of blood in the circuit. Using this dynamic assessment of the photoacoustic sO2 measurement in phantoms in relation to a ground truth, we explore the influence of multispectral processing and spectral coloring on accurate assessment of sO2. Future studies could exploit this low-cost dynamic flow phantom to validate fluence correction algorithms and explore additional blood parameters such as pH and also absorptive and other properties of different fluids.
dc.format.mediumPrint
dc.languageeng
dc.publisherSPIE-Intl Soc Optical Eng
dc.rightsAll rights reserved
dc.subjectAnimals
dc.subjectMice
dc.subjectOxygen
dc.subjectIndocyanine Green
dc.subjectMethylene Blue
dc.subjectOximetry
dc.subjectSpectrophotometry
dc.subjectPhantoms, Imaging
dc.subjectHydrogen-Ion Concentration
dc.subjectAlgorithms
dc.subjectScattering, Radiation
dc.subjectPhotoacoustic Techniques
dc.titleDevelopment of a blood oxygenation phantom for photoacoustic tomography combined with online pO2 detection and flow spectrometry.
dc.typeArticle
prism.endingPage11
prism.issueIdentifier12
prism.publicationDate2019
prism.publicationNameJ Biomed Opt
prism.startingPage1
prism.volume24
dc.identifier.doi10.17863/CAM.43914
dcterms.dateAccepted2019-09-09
rioxxterms.versionofrecord10.1117/1.JBO.24.12.121908
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-10
dc.contributor.orcidGehrung, Marcel [0000-0001-6915-9552]
dc.contributor.orcidBohndiek, Sarah [0000-0003-0371-8635]
dc.identifier.eissn1560-2281
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research UK (C14303/A17197)
pubs.funder-project-idCancer Research UK (C14303/A17197)
rioxxterms.freetoread.startdate2022-09-16


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