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dc.contributor.authorLuppi, Andreaen
dc.contributor.authorCraig, Michael Men
dc.contributor.authorPappas, Ioannisen
dc.contributor.authorFinoia, Paolaen
dc.contributor.authorWilliams, Guyen
dc.contributor.authorAllanson, Judithen
dc.contributor.authorPickard, John Den
dc.contributor.authorOwen, Adrian Men
dc.contributor.authorNaci, Lorinaen
dc.contributor.authorMenon, Daviden
dc.contributor.authorStamatakis, Emmanuelen
dc.date.accessioned2019-09-18T23:30:59Z
dc.date.available2019-09-18T23:30:59Z
dc.date.issued2019-10-10en
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/296960
dc.description.abstractProminent theories of consciousness emphasise different aspects of neurobiology, such as the integration and diversity of information processing within the brain. Here, we combine graph theory and dynamic functional connectivity to compare resting-state functional MRI data from awake volunteers, propofol-anaesthetised volunteers, and patients with disorders of consciousness, in order to identify consciousness-specific patterns of brain function. We demonstrate that cortical networks are especially affected by loss of consciousness during temporal states of high integration, exhibiting reduced functional diversity and compromised informational capacity, whereas thalamo-cortical functional disconnections emerge during states of higher segregation. Spatially, posterior regions of the brain’s default mode network exhibit reductions in both functional diversity and integration with the rest of the brain during unconsciousness. These results show that human consciousness relies on spatio-temporal interactions between brain integration and functional diversity, whose breakdown may represent a generalisable biomarker of loss of consciousness, with potential relevance for clinical practice.
dc.description.sponsorshipThis work was supported by grants from the UK Medical Research Council (U.1055.01.002.00001.01) [to AMO and JDP]; The James S. McDonnell Foundation [to AMO and JDP]; The Canada Excellence Research Chairs program (215063) [to AMO]; The Canadian Institute for Advanced research (CIFAR) [to AMO, DKM and EAS]; The National Institute for Health Research (NIHR, UK), Cambridge Biomedical Research Centre and NIHR Senior Investigator Awards [to JDP and DKM]; The British Oxygen Professorship of the Royal College of Anaesthetists [to DKM]; The Cambridge International Trust and the Howard Sidney Sussex Studentship [to MMC]; The Oon Khye Beng Ch'Hia Tsio Studentship for Research in Preventive Medicine, Downing College, University of Cambridge [to IP]; The Evelyn Trust, Cambridge and the EoE CLAHRC fellowship [to JA]; The L’Oreal-Unesco for Women in Science Excellence Research Fellowship [to LN]; The Stephen Erskine Fellowship, Queens’ College, University of Cambridge [to EAS] and the Gates Cambridge Trust [to AIL]. The research was also supported by the NIHR Brain Injury Healthcare Technology Co-operative based at Cambridge University Hospitals NHS Foundation Trust and University of Cambridge. Computing infrastructure at the Wolfson Brain Imaging Centre (WBIC-HPHI) was funded by the MRC research infrastructure award (MR/M009041/1).
dc.format.mediumElectronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectBrainen
dc.subjectHumansen
dc.subjectConsciousness Disordersen
dc.subjectUnconsciousnessen
dc.subjectPropofolen
dc.subjectAnesthetics, Intravenousen
dc.subjectMagnetic Resonance Imagingen
dc.subjectConsciousnessen
dc.subjectWakefulnessen
dc.subjectEntropyen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectYoung Adulten
dc.titleConsciousness-specific dynamic interactions of brain integration and functional diversity.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2019en
prism.publicationNameNature communicationsen
prism.startingPage4616
prism.volume10en
dc.identifier.doi10.17863/CAM.44001
dcterms.dateAccepted2019-09-16en
rioxxterms.versionofrecord10.1038/s41467-019-12658-9en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-10-10en
dc.contributor.orcidPappas, Ioannis [0000-0002-0168-7014]
dc.contributor.orcidFinoia, Paola [0000-0002-3908-9255]
dc.contributor.orcidWilliams, Guy [0000-0001-5223-6654]
dc.contributor.orcidNaci, Lorina [0000-0001-9630-3978]
dc.contributor.orcidMenon, David [0000-0002-3228-9692]
dc.contributor.orcidStamatakis, Emmanuel Andreas [0000-0001-6955-9601]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idJames S McDonnell Foundation (via MRC) (220020156)
pubs.funder-project-idJames S McDonnell Foundation (via Weill Cornell Medicine) (220020156)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M009041/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M024873/1)
cam.orpheus.successMon Jun 08 08:21:11 BST 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2022-09-18


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