Atherosclerosis imaging using PET: Insights and applications.
British journal of pharmacology
MetadataShow full item record
Sriranjan, R. S., Tarkin, J., Evans, N., Le, E., Chowdhury, M., & Rudd, J. (2019). Atherosclerosis imaging using PET: Insights and applications.. British journal of pharmacology https://doi.org/10.1111/bph.14868
Positron emission tomography (PET) imaging is able to harness biological processes to characterise high-risk features of atherosclerotic plaque prone to rupture. Current radiotracers are able to track inflammation, microcalcification, hypoxia and neoangiogenesis within vulnerable plaque. 18F-fluorodeoxyglucose (18F-FDG) is the most commonly used radiotracer in vascular studies and is employed as a surrogate marker of plaque inflammation. Increasingly, 18F-FDG and other PET tracers are also being used to provide imaging endpoints in cardiovascular interventional trials. The evolution of novel PET radiotracers, imaging protocols and hybrid scanners are likely to enable more efficient and accurate characterisation of high-risk plaque. This review explores the role of PET imaging in atherosclerosis with a focus on PET tracers utilised in clinical research and the applications of PET imaging to cardiovascular drug development.
British Heart Foundation (PG/09/083/27667)
Academy of Medical Sciences (unknown)
British Heart Foundation (FS/12/29/29463)
Evelyn Trust (unknown)
WELLCOME TRUST (104492/Z/14/Z)
Wellcome Trust (211100/Z/18/Z)
External DOI: https://doi.org/10.1111/bph.14868
This record's URL: https://www.repository.cam.ac.uk/handle/1810/296981
All rights reserved