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dc.contributor.authorFitzgerald, Rebeccaen
dc.contributor.authorRhodes, Jonathan Men
dc.date.accessioned2019-09-25T08:44:05Z
dc.date.available2019-09-25T08:44:05Z
dc.date.issued2019-06-11en
dc.identifier.issn0007-0920
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297083
dc.description.abstractOesophageal adenocarcinoma has become much more common over the past 50 years, particularly in Britain, with an unexplained male to female ratio of > 4:1. Given the use of asbestos filtration in commercial brewing and reports of its unregulated use in British public houses in the 1970's to clear draught beer "slops", we have assessed the hypothesis that ingested asbestos could be a causative factor for this increased incidence. Importantly, occupational asbestos exposure increases the risk of adenocarcinoma but not squamous cell carcinoma of the oesophagus. The presence of asbestos fibres was consistently reported in filtered beverages including beers in the 1970s and asbestos bodies have been found in gastrointestinal tissue, particularly oesophageal tissue, at autopsy. There is no reported association between the intake of alcohol and oesophageal adenocarcinoma but studies would mostly have missed exposure from draught beer before 1980. Oesophageal adenocarcinoma has some molecular similarities to pleural mesothelioma, a condition that is largely due to inhalation of asbestos fibres, including predominant loss of tumour suppressor genes rather than an increase of classical oncogenic drivers. Trends in incidence of oesophageal adenocarcinoma and mesothelioma are similar, rising rapidly over the past 50 years but now plateauing. Asbestos ingestion, either from beer consumed before around 1980, or from occupational exposure, seems a plausible causative factor for oesophageal adenocarcinoma. If this is indeed the case, its incidence should fall back to a low baseline by around 2050.
dc.languageengen
dc.language.isoenen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleIngested asbestos in filtered beer, in addition to occupational exposure, as a causative factor in oesophageal adenocarcinoma.en
dc.typeArticle
prism.endingPage1104
prism.issueIdentifier12en
prism.publicationDate2019en
prism.publicationNameBritish Journal of Canceren
prism.startingPage1099
prism.volume120en
dc.identifier.doi10.17863/CAM.44130
dcterms.dateAccepted2019-04-02en
rioxxterms.versionofrecord10.1038/s41416-019-0467-9en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-06-11en
dc.contributor.orcidFitzgerald, Rebecca [0000-0002-3434-3568]
dc.identifier.eissn1532-1827
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-05-09en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International