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dc.contributor.authorBentley, Amy Ren
dc.contributor.authorSung, Yun Jen
dc.contributor.authorBrown, Michael Ren
dc.contributor.authorWinkler, Thomas Wen
dc.contributor.authorKraja, Aldi Ten
dc.contributor.authorNtalla, Ioannaen
dc.contributor.authorSchwander, Karenen
dc.contributor.authorChasman, Daniel Ien
dc.contributor.authorLim, Eliseen
dc.contributor.authorDeng, Xuanen
dc.contributor.authorGuo, Xiuqingen
dc.contributor.authorLiu, Jingminen
dc.contributor.authorLu, Yingchangen
dc.contributor.authorCheng, Ching-Yuen
dc.contributor.authorSim, Xuelingen
dc.contributor.authorVojinovic, Dinaen
dc.contributor.authorHuffman, Jennifer Een
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dc.contributor.authorNoordam, Raymonden
dc.contributor.authorBaker, Jennaen
dc.contributor.authorChen, Guanjieen
dc.contributor.authorAschard, Huguesen
dc.contributor.authorBartz, Traci Men
dc.contributor.authorDing, Jingzhongen
dc.contributor.authorDorajoo, Rajkumaren
dc.contributor.authorManning, Alisa Ken
dc.contributor.authorRankinen, Tuomoen
dc.contributor.authorSmith, Albert Ven
dc.contributor.authorTajuddin, Salman Men
dc.contributor.authorZhao, Weien
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dc.contributor.authorEvangelou, Evangelosen
dc.contributor.authorGao, Chuanen
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dc.contributor.authorHagemeijer, Yanicken
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dc.contributor.authorHorimoto, Andrea RVRen
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dc.contributor.authorLeander, Karinen
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dc.contributor.authorLuan, Jian'anen
dc.contributor.authorLyytikäinen, Leo-Pekkaen
dc.contributor.authorMatoba, Nanaen
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dc.contributor.authorCOGENT-Kidney Consortium,en
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dc.contributor.authorEPIC-InterAct Consortium,en
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dc.contributor.authorJonas, Jost Brunoen
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dc.contributor.authorLifelines Cohort,en
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dc.contributor.authorWang, Ya Xingen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorWatkins, Hughen
dc.contributor.authorWeir, David Ren
dc.contributor.authorWickremasinghe, Ananda Ren
dc.contributor.authorWu, Tangchunen
dc.contributor.authorZeggini, Eleftheriaen
dc.contributor.authorZheng, Weien
dc.contributor.authorBouchard, Claudeen
dc.contributor.authorEvans, Michele Ken
dc.contributor.authorGudnason, Vilmunduren
dc.contributor.authorKardia, Sharon LRen
dc.contributor.authorLiu, Yongmeien
dc.contributor.authorPsaty, Bruce Men
dc.contributor.authorRidker, Paul Men
dc.contributor.authorvan Dam, Rob Men
dc.contributor.authorMook-Kanamori, Dennis Oen
dc.contributor.authorFornage, Myriamen
dc.contributor.authorProvince, Michael Aen
dc.contributor.authorKelly, Tanika Nen
dc.contributor.authorFox, Ervin Ren
dc.contributor.authorHayward, Carolineen
dc.contributor.authorvan Duijn, Cornelia Men
dc.contributor.authorTai, E Shyongen
dc.contributor.authorWong, Tien Yinen
dc.contributor.authorLoos, Ruth JFen
dc.contributor.authorFranceschini, Noraen
dc.contributor.authorRotter, Jerome Ien
dc.contributor.authorZhu, Xiaofengen
dc.contributor.authorBierut, Laura Jen
dc.contributor.authorGauderman, W Jamesen
dc.contributor.authorRice, Kennethen
dc.contributor.authorMunroe, Patricia Ben
dc.contributor.authorMorrison, Alanna Cen
dc.contributor.authorRao, Dabeeru Cen
dc.contributor.authorRotimi, Charles Nen
dc.contributor.authorCupples, L Adrienneen
dc.date.accessioned2019-09-27T23:30:51Z
dc.date.available2019-09-27T23:30:51Z
dc.date.issued2019-04en
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297278
dc.description.abstractThe concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
dc.description.sponsorshipThis project was largely supported by a grant from the US National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL118305) and by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (Z01HG200362).
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectFemaleen
dc.subjectGenome-Wide Association Studyen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectLife Styleen
dc.subjectLinkage Disequilibriumen
dc.subjectLipidsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectSmokingen
dc.subjectYoung Adulten
dc.titleMulti-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.en
dc.typeArticle
prism.endingPage648
prism.issueIdentifier4en
prism.publicationDate2019en
prism.publicationNameNature Geneticsen
prism.startingPage636
prism.volume51en
dc.identifier.doi10.17863/CAM.44325
dcterms.dateAccepted2019-02-07en
rioxxterms.versionofrecord10.1038/s41588-019-0378-yen
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-04en
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidZhao, Jing Hua [0000-0003-4930-3582]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1546-1718
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_PC_13048)
pubs.funder-project-idMRC (MC_PC_13046)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
cam.issuedOnline2019-03-29en
rioxxterms.freetoread.startdate2019-10-30


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