Genetic Liability to Insomnia and Cardiovascular Disease Risk.
Larsson, Susanna C
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Larsson, S. C., & Markus, H. (2019). Genetic Liability to Insomnia and Cardiovascular Disease Risk.. Circulation, 140 (9), 796-798. https://doi.org/10.1161/CIRCULATIONAHA.119.041830
Insomnia is an important public health problem affecting ≈10% to 30% of the general population.1 Evidence from observational studies indicates that insomnia is associated with an increased risk of cardiovascular disease (CVD). However, whether the association is causal is unknown because observational studies are hampered by reverse causation bias and residual confounding. Self-reported insomnia may be correlated with confounding factors, such as socioeconomic position, chronic illness, and lifestyle factors that may bias the observational findings.
Mendelian randomization analysis, cardiovascular diseases, sleep, sleep initiation and maintenance disorders, stroke
Funding for this study came from the Swedish Research Council for Health, Working Life and Welfare (Forte) (grant no. 2018-00123), the Swedish Research Council, and a British Heart Foundation programme grant (grant no. RG/16/4/32218). Hugh Markus is supported by a National Institute for Health Research Senior Investigator award, and his work is supported by infrastructural support from the Cambridge University Hospitals Trust National Institute for Health Research Biomedical Research Centre.
British Heart Foundation (RG/16/4/32218)
External DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.041830
This record's URL: https://www.repository.cam.ac.uk/handle/1810/297349
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