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dc.contributor.authorde Nijs, Barten
dc.contributor.authorCarnegie, Cloudyen
dc.contributor.authorSzabó, Istvánen
dc.contributor.authorGrys, David-Benjaminen
dc.contributor.authorChikkaraddy, Rohiten
dc.contributor.authorKamp, Marlousen
dc.contributor.authorBarrow, Steven Jen
dc.contributor.authorReadman, Charlesen
dc.contributor.authorKleemann, Marie-Elenaen
dc.contributor.authorScherman, Orenen
dc.contributor.authorRosta, Edinaen
dc.contributor.authorBaumberg, Jeremyen
dc.date.accessioned2019-10-03T23:30:46Z
dc.date.available2019-10-03T23:30:46Z
dc.date.issued2019-11en
dc.identifier.issn2379-3694
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297437
dc.description.abstractQuantitative applications of surface enhanced Raman spectroscopy (SERS) often rely on surface partition layers grafted to SERS substrates to collect and trap solvated analytes that would not otherwise adsorb onto metals. Such binding layers drastically broaden the scope of analytes that can be probed. However, excess binding sites introduced by this partition layer also trap analytes outside the plasmonic ‘hot-spots’. We show that by eliminating these binding sites, limits of detection (LODs) can effectively be lowered by more than an order of magnitude. We highlight the effectiveness of this approach by demonstrating quantitative detection of controlled drugs down to sub-nanomolar concentrations in aqueous media. Such LODs are low enough to screen, for example, urine at clinically relevant levels. These findings provide unique insights into the binding behavior of analytes, which are essential when designing high performance SERS substrates.
dc.description.sponsorshipIn addition to the EPSRC funding B.d.N acknowledges support from the Leverhulme Trust and Isaac Newton Trust, C.C. acknowledges support from NPL (PO443073), R.C. acknowledges support from the Dr. Manmohan Singh scholarship from St. John’s College, M.K. thanks the European Commission for a Marie Skłodowska-Curie Fellowship (SPARCLEs, 7020005), S.J.B. thanks the European Commission for a Marie Skłodowska-Curie Fellowship (NANOSPHERE, 658360).
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherAmerican Chemical Society
dc.rightsAll rights reserved
dc.rights.uri
dc.titleInhibiting Analyte Theft in Surface-Enhanced Raman Spectroscopy Substrates: Subnanomolar Quantitative Drug Detection.en
dc.typeArticle
prism.endingPage2996
prism.issueIdentifier11en
prism.publicationDate2019en
prism.publicationNameACS sensorsen
prism.startingPage2988
prism.volume4en
dc.identifier.doi10.17863/CAM.44498
dcterms.dateAccepted2019-09-26en
rioxxterms.versionofrecord10.1021/acssensors.9b01484en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-11en
dc.contributor.orcidSzabó, István [0000-0002-3700-3614]
dc.contributor.orcidGrys, David-Benjamin [0000-0002-4038-6388]
dc.contributor.orcidChikkaraddy, Rohit [0000-0002-3840-4188]
dc.contributor.orcidKamp, Marlous [0000-0003-4915-1312]
dc.contributor.orcidBarrow, Steven J [0000-0001-6417-1800]
dc.contributor.orcidReadman, Charles [0000-0001-9743-9180]
dc.contributor.orcidScherman, Oren [0000-0001-8032-7166]
dc.contributor.orcidRosta, Edina [0000-0002-9823-4766]
dc.contributor.orcidBaumberg, Jeremy [0000-0002-9606-9488]
dc.identifier.eissn2379-3694
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/L027151/1)
pubs.funder-project-idIsaac Newton Trust (18.08(K))
pubs.funder-project-idLeverhulme Trust (ECF-2018-021)
pubs.funder-project-idEuropean Commission (658360)
pubs.funder-project-idEPSRC (EP/L015978/1)
pubs.funder-project-idEPSRC (via University of Exeter) (EP/R020965/1)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (702005)
pubs.funder-project-idEPSRC (EP/L015889/1)
cam.orpheus.successThu Jan 30 10:37:32 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-11-30


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