The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia.

Muriuki, John Muthii; Mentzer, Alexander J; Band, Gavin; Gilchrist, James J; Carstensen, Tommy; Lule, Swaib A; Goheen, Morgan M; Joof, Fatou; Kimita, Wandia; Mogire, Reagan; Cutland, Clare L; Diarra, Amidou; Rautanen, Anna; Pomilla, Cristina; Gurdasani, Deepti; Rockett, Kirk; Mturi, Neema; Ndungu, Francis M; Scott, J Anthony G; Sirima, Sodiomon B; Morovat, Alireza; Prentice, Andrew M; Madhi, Shabir A; Webb, Emily L; Elliott, Alison M; Bejon, Philip; Sandhu, Manjinder; Hill, Adrian VS; Kwiatkowski, Dominic P; Williams, Thomas N; Cerami, Carla; Atkinson, Sarah H

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Authors

Muriuki, John Muthii

Mentzer, Alexander J

Band, Gavin

Gilchrist, James J

Carstensen, Tommy

Lule, Swaib A

Goheen, Morgan M

Publication Date

2019-09-04

Journal Title

Science advances

ISSN

2375-2548

Volume

Issue

Pages

eaaw0109

Language

eng

Type

Article

This Version

VoR

Physical Medium

Electronic-eCollection

Metadata

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Citation

Muriuki, J. M., Mentzer, A. J., Band, G., Gilchrist, J. J., Carstensen, T., Lule, S. A., Goheen, M. M., et al. (2019). The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia.. Science advances, 5 (9), eaaw0109. https://doi.org/10.1126/sciadv.aaw0109

Keywords

Erythrocytes, Humans, Bacteremia, Malaria, Anemia, Iron, Cation Transport Proteins, Amino Acid Substitution, Mutation, Missense, Infant, Infant, Newborn, Female, Male

Sponsorship

MRC (G0901213)

MRC (MR/K013491/1)

Wellcome Trust (090770/Z/09/Z)

WELLCOME TRUST (107743/Z/15/Z)

Identifiers

External DOI: https://doi.org/10.1126/sciadv.aaw0109

This record's URL: https://www.repository.cam.ac.uk/handle/1810/297440

Rights

Attribution 4.0 International

Licence URL: https://creativecommons.org/licenses/by/4.0/

Except where otherwise noted, this item's licence is described as Attribution 4.0 International