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Experimental and Computational Approaches to Direct Cell Reprogramming: Recent Advancement and Future Challenges.

Published version
Peer-reviewed

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Type

Article

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Authors

Gam, Rihab 
Prasad Pandurangan, Arun 

Abstract

The process of direct cell reprogramming, also named transdifferentiation, permits for the conversion of one mature cell type directly into another, without returning to a dedifferentiated state. This makes direct reprogramming a promising approach for the development of several cellular and tissue engineering therapies. To achieve the change in the cell identity, direct reprogramming requires an arsenal of tools that combine experimental and computational techniques. In the recent years, several methods of transdifferentiation have been developed. In this review, we will introduce the concept of direct cell reprogramming and its background, and cover the recent developments in the experimental and computational prediction techniques with their applications. We also discuss the challenges of translating this technology to clinical setting, accompanied with potential solutions.

Description

Keywords

cell therapy, computational biology, direct reprogramming, regenerative medicine, transdifferentiation, Animals, Cell Transdifferentiation, Cellular Reprogramming Techniques, Computational Biology, Epigenesis, Genetic, Humans, Induced Pluripotent Stem Cells

Journal Title

Cells

Conference Name

Journal ISSN

2073-4409
2073-4409

Volume Title

8

Publisher

MDPI AG