Virus evolution in Wolbachia-infected Drosophila.
Smith, Sophia CL
Proceedings. Biological sciences
Royal Society Publishing
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Martinez, J., Bruner-Montero, G., Arunkumar, R., Smith, S. C., Day, J., Longdon, B., & Jiggins, F. (2019). Virus evolution in Wolbachia-infected Drosophila.. Proceedings. Biological sciences, 286 (1914), 20192117. https://doi.org/10.1098/rspb.2019.2117
Wolbachia, a common vertically transmitted symbiont, can protect insects against viral infection and prevent mosquitoes from transmitting viral pathogens. For this reason, Wolbachia-infected mosquitoes are being released to prevent the transmission of dengue and other arboviruses. An important question for the long-term success of these programs is whether viruses can evolve to escape the antiviral effects of Wolbachia. We have found that Wolbachia altered the outcome of competition between strains of the DCV virus in Drosophila. However, Wolbachia still effectively blocked the virus genotypes that were favoured in the presence of the symbiont. We conclude that Wolbachia did cause an evolutionary response in viruses but this has little or no impact on the effectiveness of virus-blocking.
Animals, Culicidae, Aedes, Drosophila, Wolbachia, Viruses, Virus Diseases, Symbiosis
This study was funded by the Wellcome Trust grant WT094664MA (http://www.wellcome.ac.uk/) and the European Research Council (ERC) grant 281668 DrosophilaInfection.
Wellcome Trust (094664/Z/10/Z)
European Research Council (281668)
External DOI: https://doi.org/10.1098/rspb.2019.2117
This record's URL: https://www.repository.cam.ac.uk/handle/1810/297666
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