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dc.contributor.authorAiroldi, Chiaraen
dc.contributor.authorHearn, Timothyen
dc.contributor.authorBrockington, Samuelen
dc.contributor.authorWebb, Alexen
dc.contributor.authorGlover, Beverleyen
dc.date.accessioned2019-10-14T23:30:30Z
dc.date.available2019-10-14T23:30:30Z
dc.date.issued2019-11-11en
dc.identifier.issn2055-026X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297820
dc.description.abstractThe Arabidopsis genome contains three members of the TTG1 (TRANSPARENT TESTA GLABRA 1) WDR subgroup of the WDR family, with very different reported roles. TTG1 is a regulator of epidermal cell differentiation, and of the production of pigments, while LWD1 (LIGHT-REGULATED WD1) and LWD2 (LIGHT-REGULATED WD2) are regulators of the circadian clock. We discovered a new central role for TTG1 WDR proteins as regulators of the circadian system, demonstrated by a lack of detectable circadian rhythms in a triple lwd1lwd2ttg1 mutant. We have demonstrated that there has been subfunctionalisation by protein changes within the angiosperms, with some TTG1 WDR proteins developing a stronger role in circadian clock regulation while losing the protein characteristics essential for pigment production and epidermal cell specification, and others weakening their ability to drive circadian clock regulation. Our work demonstrates that even where proteins are very conserved, small changes can drive big functional differences.
dc.description.sponsorshipCAA acknowledges support from the Cambridge University Botanic Garden Research Fund. TJH was supported by BBSRC UK grant BB/M006212/1 awarded to AARW.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectArabidopsisen
dc.subjectPlant Epidermisen
dc.subjectArabidopsis Proteinsen
dc.subjectPigmentationen
dc.subjectCell Differentiationen
dc.subjectPlant Cellsen
dc.titleTTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation.en
dc.typeArticle
prism.endingPage1153
prism.issueIdentifier11en
prism.publicationDate2019en
prism.publicationNameNature plantsen
prism.startingPage1145
prism.volume5en
dc.identifier.doi10.17863/CAM.44874
dcterms.dateAccepted2019-10-08en
rioxxterms.versionofrecord10.1038/s41477-019-0544-3en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-11-11en
dc.contributor.orcidAiroldi, Chiara [0000-0003-3749-0974]
dc.contributor.orcidHearn, Timothy [0000-0001-6827-4196]
dc.contributor.orcidBrockington, Samuel [0000-0003-1216-219X]
dc.contributor.orcidWebb, Alexander [0000-0003-0261-4375]
dc.contributor.orcidGlover, Beverley [0000-0002-6393-819X]
dc.identifier.eissn2055-0278
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idLeverhulme Trust (RPG-2018-318)
pubs.funder-project-idBBSRC (BB/M006212/1)
cam.orpheus.successThu Jan 30 10:38:44 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-05-11


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