Low-frequency variation in TP53 has large effects on head circumference and intracranial volume.

Haworth, Simon; Shapland, Chin Yang; Hayward, Caroline; Prins, Bram; Felix, Janine F; Medina-Gomez, Carolina; Rivadeneira, Fernando; Wang, Carol; Ahluwalia, Tarunveer S; Vrijheid, Martine; Guxens, Mònica; Sunyer, Jordi; Tachmazidou, Ioanna; Walter, Klaudia; Iotchkova, Valentina; Jackson, Andrew; Cleal, Louise; Huffmann, Jennifer; Min, Josine L; Sass, Lærke; Timmers, Paul RHJ; UK10K consortium,; Davey Smith, George; Fisher, Simon E; Wilson, James F; Cole, Tim J; Fernandez-Orth, Dietmar; Bønnelykke, Klaus; Bisgaard, Hans; Pennell, Craig E; Jaddoe, Vincent WV; Dedoussis, George; Timpson, Nicholas; Zeggini, Eleftheria; Vitart, Veronique; St Pourcain, Beate

View / Open Files

Published version (PDF, 1Mb)

Authors

Haworth, Simon

Shapland, Chin Yang

Hayward, Caroline

Prins, Bram

Felix, Janine F

Medina-Gomez, Carolina

Rivadeneira, Fernando

Publication Date

2019-01-21

Journal Title

Nature communications

ISSN

2041-1723

Volume

Issue

Pages

357

Language

eng

Type

Article

This Version

VoR

Physical Medium

Electronic

Metadata

Show full item record

Citation

Haworth, S., Shapland, C. Y., Hayward, C., Prins, B., Felix, J. F., Medina-Gomez, C., Rivadeneira, F., et al. (2019). Low-frequency variation in TP53 has large effects on head circumference and intracranial volume.. Nature communications, 10 (1), 357. https://doi.org/10.1038/s41467-018-07863-x

Keywords

UK10K consortium, Skull, Humans, RNA, Messenger, Cephalometry, Gene Expression Regulation, Developmental, Gene Frequency, Alleles, Genome, Human, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, European Continental Ancestry Group, Female, Male, Tumor Suppressor Protein p53, Genetic Variation, Genetic Loci

Sponsorship

Wellcome Trust (unknown)

Wellcome Trust (207462/Z/17/Z)

Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)

Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)

MRC (G9824984)

MRC (MC_UU_12012/5)

Identifiers

External DOI: https://doi.org/10.1038/s41467-018-07863-x

This record's URL: https://www.repository.cam.ac.uk/handle/1810/297827

Rights

Attribution 4.0 International

Licence URL: https://creativecommons.org/licenses/by/4.0/

Except where otherwise noted, this item's licence is described as Attribution 4.0 International