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dc.contributor.authorHouldcroft, Charlotte
dc.date.accessioned2019-10-21T23:30:34Z
dc.date.available2019-10-21T23:30:34Z
dc.date.issued2019-10-14
dc.identifier.issn2076-0817
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297958
dc.description.abstractThe nine human herpesviruses are some of the most ubiquitous pathogens worldwide, causing life-long latent infection in a variety of different tissues. Human herpesviruses range from mild childhood infections to known tumour viruses and ‘trolls of transplantation’. Epstein-Barr virus was the first human herpesvirus to have its whole genome sequenced; GenBank now includes thousands of herpesvirus genomes. This review will cover some of the recent advances in our understanding of herpesvirus diversity and disease that have come about as a result of new sequencing technologies, such as target enrichment and long-read sequencing. It will also look at the problem of resolving mixed-genotype infections, whether with short or long-read sequencing methods; and conclude with some thoughts on the future of the field as herpesvirus population genomics becomes a reality.
dc.description.sponsorshipThis research received no external funding.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHuman Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
dc.typeArticle
prism.issueIdentifier4
prism.number186
prism.publicationDate2019
prism.publicationNamePathogens
prism.volume8
dc.identifier.doi10.17863/CAM.45012
dcterms.dateAccepted2019-10-11
rioxxterms.versionofrecord10.3390/pathogens8040186
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-10-14
dc.contributor.orcidHouldcroft, Charlotte [0000-0002-1833-5285]
dc.identifier.eissn2076-0817
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (via University College London (UCL)) (Ref 17/0008 539724)
cam.issuedOnline2019-10-12


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International