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dc.contributor.authorHagen, Ferry
dc.contributor.authorCeresini, Paulo C
dc.contributor.authorPolacheck, Itzhack
dc.contributor.authorMa, Hansong
dc.contributor.authorvan Nieuwerburgh, Filip
dc.contributor.authorGabaldón, Toni
dc.contributor.authorKagan, Sarah
dc.contributor.authorPursall, E Rhiannon
dc.contributor.authorHoogveld, Hans L
dc.contributor.authorvan Iersel, Leo JJ
dc.contributor.authorKlau, Gunnar W
dc.contributor.authorKelk, Steven M
dc.contributor.authorStougie, Leen
dc.contributor.authorBartlett, Karen H
dc.contributor.authorVoelz, Kerstin
dc.contributor.authorPryszcz, Leszek P
dc.contributor.authorCastañeda, Elizabeth
dc.contributor.authorLazera, Marcia
dc.contributor.authorMeyer, Wieland
dc.contributor.authorDeforce, Dieter
dc.contributor.authorMeis, Jacques F
dc.contributor.authorMay, Robin C
dc.contributor.authorKlaassen, Corné HW
dc.contributor.authorBoekhout, Teun
dc.date.accessioned2019-10-22T23:30:19Z
dc.date.available2019-10-22T23:30:19Z
dc.date.issued2013
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297983
dc.description.abstractOver the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.
dc.format.mediumElectronic-Print
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCells, Cultured
dc.subjectMacrophages
dc.subjectAnimals
dc.subjectMice, Inbred BALB C
dc.subjectHumans
dc.subjectMice
dc.subjectTrees
dc.subjectCryptococcosis
dc.subjectMycological Typing Techniques
dc.subjectLikelihood Functions
dc.subjectTropical Climate
dc.subjectDisease Outbreaks
dc.subjectPhylogeny
dc.subjectVirulence
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectGenes, Fungal
dc.subjectMolecular Sequence Data
dc.subjectBritish Columbia
dc.subjectNorthwestern United States
dc.subjectBrazil
dc.subjectCryptococcus gattii
dc.subjectMultilocus Sequence Typing
dc.titleAncient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
dc.typeArticle
prism.issueIdentifier8
prism.publicationDate2013
prism.publicationNamePLoS One
prism.startingPagee71148
prism.volume8
dc.identifier.doi10.17863/CAM.45039
dcterms.dateAccepted2013-06-25
rioxxterms.versionofrecord10.1371/journal.pone.0071148
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2013-01
dc.contributor.orcidMa, Hansong [0000-0002-2705-1970]
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Review
cam.issuedOnline2013-08-07


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International