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dc.contributor.authorSeddighi, Sahbaen
dc.contributor.authorHouck, Alexander Len
dc.contributor.authorRowe, Jamesen
dc.contributor.authorPharoah, Paulen
dc.date.accessioned2019-10-22T23:30:24Z
dc.date.available2019-10-22T23:30:24Z
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297987
dc.description.abstractWhile limited observational evidence suggests that cancer survivors have a decreased risk of developing Alzheimer's disease (AD), and vice versa, it is not clear whether this relationship is causal. Using a Mendelian randomization approach that provides evidence of causality, we found that genetically predicted lung cancer (OR 0.91, 95% CI 0.84-0.99, p = 0.019), leukemia (OR 0.98, 95% CI 0.96-0.995, p = 0.012), and breast cancer (OR 0.94, 95% CI 0.89-0.99, p = 0.028) were associated with 9.0%, 2.4%, and 5.9% lower odds of AD, respectively, per 1-unit higher log odds of cancer. When genetic predictors of all cancers were pooled, cancer was associated with 2.5% lower odds of AD (OR 0.98, 95% CI 0.96-0.988, p = 0.00027) per 1-unit higher log odds of cancer. Finally, genetically predicted smoking-related cancers showed a more robust inverse association with AD than non-smoking related cancers (OR 0.95, 95% CI 0.92-0.98, p = 0.0026, vs. OR 0.98, 95% CI 0.97-0.995, p = 0.0091).
dc.description.sponsorshipThis project was supported by a Gates Cambridge Trust grant to SS (OPP1144). JBR is supported by the Wellcome Trust (103838). PDPP has infrastructural support from Cambridge University and Cancer Research UK.
dc.languageengen
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEvidence of a Causal Association Between Cancer and Alzheimer's Disease: a Mendelian Randomization Analysis.en
dc.typeArticle
prism.issueIdentifier1en
prism.number13548en
prism.publicationNameScientific Reportsen
prism.volume9en
dc.identifier.doi10.17863/CAM.45043
dcterms.dateAccepted2019-08-29en
rioxxterms.versionofrecord10.1038/s41598-019-49795-6en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-08-29en
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
cam.issuedOnline2019-09-19en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International