The association between frailty and MRI features of cerebral small vessel disease.
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Authors
Kant, Ilse MJ
van Montfort, Simone JT
Jaarsma-Coes, Myriam G
Witkamp, Theodoor D
Winterer, Georg
Hendrikse, Jeroen
Slooter, Arjen JC
BioCog Consortium
Publication Date
2019-08-05Journal Title
Sci Rep
ISSN
2045-2322
Publisher
Springer Science and Business Media LLC
Volume
9
Issue
1
Pages
11343
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Kant, I. M., Mutsaerts, H. J., van Montfort, S. J., Jaarsma-Coes, M. G., Witkamp, T. D., Winterer, G., Spies, C. D., et al. (2019). The association between frailty and MRI features of cerebral small vessel disease.. Sci Rep, 9 (1), 11343. https://doi.org/10.1038/s41598-019-47731-2
Abstract
Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between frailty and MRI features of cerebral small vessel disease in a group of non-demented older individuals. We included 170 participants who were classified as frail (n = 30), pre-frail (n = 85) or non-frail (n = 55). The association of frailty and white matter hyperintensity volume and shape features, lacunar infarcts and cerebral perfusion was investigated by regression analyses adjusted for age and sex. Frail and pre-frail participants were older, more often female and showed higher white matter hyperintensity volume (0.69 [95%-CI 0.08 to 1.31], p = 0.03 respectively 0.43 [95%-CI: 0.04 to 0.82], p = 0.03) compared to non-frail participants. Frail participants showed a non-significant trend, and pre-frail participants showed a more complex shape of white matter hyperintensities (concavity index: 0.04 [95%-CI: 0.03 to 0.08], p = 0.03; fractal dimensions: 0.07 [95%-CI: 0.00 to 0.15], p = 0.05) compared to non-frail participants. No between group differences were found in gray matter perfusion or in the presence of lacunar infarcts. In conclusion, increased white matter hyperintensity volume and a more complex white matter hyperintensity shape may be structural brain correlates of the frailty phenotype.
Keywords
BioCog Consortium, Brain, Humans, Magnetic Resonance Imaging, Aged, Frail Elderly, Female, Male, Cerebral Small Vessel Diseases, White Matter, Frailty
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Identifiers
External DOI: https://doi.org/10.1038/s41598-019-47731-2
This record's URL: https://www.repository.cam.ac.uk/handle/1810/298010
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