De-fusing mitochondria defuses the mtDNA time-bomb.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Chinnery, Patrick F
Prudent, Julien https://orcid.org/0000-0003-3821-6088
Abstract
Being uniparentally inherited and with a high mutation rate, mitochondrial DNA (mtDNA) should relentlessly acquire mutations, eventually destroying a species through “mutational meltdown”. Lieber et al. now show that mitochondrial fragmentation is an essential first step in Drosophila , preventing functional complementation by wild-type molecules, and packaging mutations into mitochondria before they are destroyed by mitophagy.
Description
Keywords
DNA, Mitochondrial, Germ Cells, Mitochondria
Journal Title
Cell Research
Conference Name
Journal ISSN
1001-0602
1748-7838
1748-7838
Volume Title
29
Publisher
Springer Nature
Publisher DOI
Sponsorship
Medical Research Council (MC_UU_00015/7)