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De-fusing mitochondria defuses the mtDNA time-bomb.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Chinnery, Patrick F 

Abstract

Being uniparentally inherited and with a high mutation rate, mitochondrial DNA (mtDNA) should relentlessly acquire mutations, eventually destroying a species through “mutational meltdown”. Lieber et al. now show that mitochondrial fragmentation is an essential first step in Drosophila , preventing functional complementation by wild-type molecules, and packaging mutations into mitochondria before they are destroyed by mitophagy.

Description

Keywords

DNA, Mitochondrial, Germ Cells, Mitochondria

Journal Title

Cell Research

Conference Name

Journal ISSN

1001-0602
1748-7838

Volume Title

29

Publisher

Springer Nature
Sponsorship
Medical Research Council (MC_UU_00015/7)