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dc.contributor.authorFodor, Ervinen
dc.contributor.authorte Velthuis, Arenden
dc.date.accessioned2019-10-25T23:30:19Z
dc.date.available2019-10-25T23:30:19Z
dc.date.issued2020-09en
dc.identifier.issn2157-1422
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/298086
dc.description.abstractTranscription and replication of the influenza virus RNA genome is catalysed by the viral heterotrimeric RNA-dependent RNA polymerase in the context of viral ribonucleoprotein (vRNP) complexes. Atomic resolution structures of the viral RNA synthesis machinery have offered insights into the initiation mechanisms of viral transcription and genome replication, and the interaction of the viral RNA polymerase with host RNA polymerase II, which is required for the initiation of viral transcription. Replication of the viral RNA genome by the viral RNA polymerase depends on host ANP32A, and host-specific sequence differences in ANP32A underlie the poor activity of avian influenza virus polymerases in mammalian cells. A failure to faithfully copy the viral genome segments can lead to the production aberrant viral RNA products, such as defective interfering (DI) RNAs and mini viral RNAs (mvRNAs). Both aberrant RNA types have been implicated in innate immune responses against influenza virus infection. This chapter discusses recent insights into the structure-function relationship of the viral RNA polymerase and its role in determining host range and virulence.
dc.description.sponsorshipE. Fodor is supported by UK Medical Research Council programme grant MR/R009945/1. A. te Velthuis is supported by joint Wellcome Trust and Royal Society grant 206579/Z/17/Z, Isaac Newton Trust grant 17.37(r), and the National Institutes of Health grant R21AI147172.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherCold Spring Harbor Laboratory Press
dc.rightsAll rights reserved
dc.rights.uri
dc.titleStructure and Function of the Influenza Virus Transcription and Replication Machinery.en
dc.typeArticle
prism.issueIdentifier9en
prism.publicationDate2020en
prism.publicationNameCold Spring Harbor perspectives in medicineen
prism.volume10en
dc.identifier.doi10.17863/CAM.45144
dcterms.dateAccepted2019-10-11en
rioxxterms.versionofrecord10.1101/cshperspect.a038398en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-09en
dc.contributor.orcidte Velthuis, Arend [0000-0002-5129-3953]
dc.identifier.eissn2157-1422
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (206579/Z/17/Z)
pubs.funder-project-idIsaac Newton Trust (17.37 (r))
rioxxterms.freetoread.startdate2022-10-25


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