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dc.contributor.authorNicol, Dianneen
dc.contributor.authorEckstein, Lisaen
dc.contributor.authorMorrison, Michaelen
dc.contributor.authorSherkow, Jacob Sen
dc.contributor.authorOtlowski, Margareten
dc.contributor.authorWhitton, Tessen
dc.contributor.authorBubela, Taniaen
dc.contributor.authorBurdon, Kathryn Pen
dc.contributor.authorChalmers, Donen
dc.contributor.authorChan, Sarahen
dc.contributor.authorCharlesworth, Jacen
dc.contributor.authorCritchley, Christineen
dc.contributor.authorCrossley, Merlinen
dc.contributor.authorde Lacey, Sherylen
dc.contributor.authorDickinson, Joanne Len
dc.contributor.authorHewitt, Alex Wen
dc.contributor.authorKamens, Joanneen
dc.contributor.authorKato, Kazutoen
dc.contributor.authorKleiderman, Erikaen
dc.contributor.authorKodama, Satoshien
dc.contributor.authorLiddicoat, Johnen
dc.contributor.authorMackey, David Aen
dc.contributor.authorNewson, Ainsley Jen
dc.contributor.authorNielsen, Janeen
dc.contributor.authorWagner, Jennifer Ken
dc.contributor.authorMcWhirter, Rebekah Een
dc.date.accessioned2019-10-29T00:31:12Z
dc.date.available2019-10-29T00:31:12Z
dc.date.issued2017-09-25en
dc.identifier.issn1756-994X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/298137
dc.description.abstractGenome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.
dc.format.mediumElectronicen
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumansen
dc.subjectClinical Medicineen
dc.subjectIntellectual Propertyen
dc.subjectBiomedical Technologyen
dc.subjectCell- and Tissue-Based Therapyen
dc.subjectClustered Regularly Interspaced Short Palindromic Repeatsen
dc.titleKey challenges in bringing CRISPR-mediated somatic cell therapy into the clinic.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2017en
prism.publicationNameGenome medicineen
prism.startingPage85
prism.volume9en
dc.identifier.doi10.17863/CAM.45194
dcterms.dateAccepted2017-06-06en
rioxxterms.versionofrecord10.1186/s13073-017-0475-4en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-09-25en
dc.contributor.orcidNicol, Dianne [0000-0002-6553-2839]
dc.contributor.orcidEckstein, Lisa [0000-0002-7161-7521]
dc.contributor.orcidMorrison, Michael [0000-0001-6870-6673]
dc.contributor.orcidSherkow, Jacob S [0000-0002-9724-9261]
dc.contributor.orcidWhitton, Tess [0000-0001-6397-6965]
dc.contributor.orcidBubela, Tania [0000-0002-0807-2899]
dc.contributor.orcidCrossley, Merlin [0000-0003-2057-3642]
dc.contributor.orcidde Lacey, Sheryl [0000-0002-5652-9451]
dc.contributor.orcidHewitt, Alex W [0000-0002-5123-5999]
dc.contributor.orcidKamens, Joanne [0000-0002-7000-1477]
dc.contributor.orcidKato, Kazuto [0000-0001-9006-9551]
dc.contributor.orcidLiddicoat, Johnathon [0000-0001-7370-3936]
dc.contributor.orcidMackey, David A [0000-0001-7914-4709]
dc.contributor.orcidNewson, Ainsley J [0000-0002-3460-772X]
dc.contributor.orcidMcWhirter, Rebekah E [0000-0002-9409-8074]
dc.identifier.eissn1756-994X
rioxxterms.typeJournal Article/Reviewen


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International