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Removing rician bias in diffusional kurtosis of the prostate using real-data reconstruction.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Barrett, Tristan 
Patterson, Ilse 
Gallagher, Ferdia A 
Lawrence, Edward M 

Abstract

PURPOSE: To compare prostate diffusional kurtosis imaging (DKI) metrics generated using phase-corrected real data with those generated using magnitude data with and without noise compensation (NC). METHODS: Diffusion-weighted images were acquired at 3T in 16 prostate cancer patients, measuring 6 b-values (0-1500 s/mm2 ), each acquired with 6 signal averages along 3 diffusion directions, with noise-only images acquired to allow NC. In addition to conventional magnitude averaging, phase-corrected real data were averaged in an attempt to reduce rician noise-bias, with a range of phase-correction low-pass filter (LPF) sizes (8-128 pixels) tested. Each method was also tested using simulations. Pixelwise maps of apparent diffusion (D) and apparent kurtosis (K) were calculated for magnitude data with and without NC and phase-corrected real data. Average values were compared in tumor, normal transition zone (NTZ), and normal peripheral zone (NPZ). RESULTS: Simulations indicated LPF size can strongly affect K metrics, where 64-pixel LPFs produced accurate metrics. Relative to metrics estimated from magnitude data without NC, median NC K were lower (P < 0.0001) by 6/11/8% in tumor/NPZ/NTZ, 64-LPF real-data K were lower (P < 0.0001) by 4/10/7%, respectively. CONCLUSION: Compared with magnitude data with NC, phase-corrected real data can produce similar K, although the choice of phase-correction LPF should be chosen carefully.

Description

Keywords

diffusion weighted MRI, diffusional kurtosis MRI, prostate cancer, quantitative imaging, Diffusion, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Humans, Male, Prostatic Neoplasms

Journal Title

Magn Reson Med

Conference Name

Journal ISSN

0740-3194
1522-2594

Volume Title

83

Publisher

Wiley

Rights

All rights reserved
Sponsorship
Prostate Cancer UK (PA14-012)
Cancer Research UK (C12912/A27150)
Cambridge University Hospitals NHS Foundation Trust (CUH) (3819-1819-07)