Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism.
Palmeira, Carlos M
Fernandes, Ana S
MetadataShow full item record
Almeida, N., Carrara, G., Palmeira, C. M., Fernandes, A. S., Parsons, M., Smith, G., & Saraiva, N. (2020). Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism.. Redox biology, 28 101361. https://doi.org/10.1016/j.redox.2019.101361
The mechanisms by which the Golgi apparatus (GA) impacts on cell invasion are The mechanisms by which the Golgi apparatus (GA) impacts on cell invasion are TMBIM4) is a highly conserved Golgi cation channel that modulates intracellular Ca2+ fluxes. Human GAAP is expressed in all human tissues, is essential for cell viability and provides resistance against a range of apoptotic stresses. Furthermore, hGAAP enhances adhesion and cell migration by increasing the turnover of focal adhesions due to activation of store-operated Ca2+ entry. Here, we describe a GA-derived mechanism that controls cell invasion. The overexpression of hGAAP stimulates 3-dimensional proteolytic cell invasion by a mechanism that is dependent on the accumulation of intracellular hydrogen peroxide, which might be produced by the hGAAP-dependent stimulation of mitochondrial respiration. These findings provide new insight into the complex mechanisms by which Ca2+ and reactive oxygen species signaling contribute to cell invasion and to the role of the GA in these processes.
Wellcome Trust (090315/B/09/Z)
WELLCOME TRUST (090315/B/09/A)
Embargo Lift Date
External DOI: https://doi.org/10.1016/j.redox.2019.101361
This record's URL: https://www.repository.cam.ac.uk/handle/1810/298207
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/