The current understanding of the role of the cell membrane is in a state of flux. Recent experiments show how conventional models, considering only electrophysiological properties of a passive membrane, are incomplete. The neuronal membrane is an active structure with mechanical properties that shape electrophysiology, e.g., protein transport, lipid conformational state, membrane pressure and stiffness can all influence membrane capacitance and potential propagation. A mounting body of evidence indicates that neuronal mechanics and electrophysiology are coupled, together shaping the membrane potential in tight coordination with other physics. In this review, we summarise recent updates concerning electrophysiological-mechanical coupling in neuronal function. In particular, we aim at making the link with two relevant yet often disconnected fields with strong clinical potential: the use of mechanical vibrations—ultrasound—to alter the electrophysiogical state of neurons, e.g., in neuromodulation, and the theories attempting to explain the action of general anaesthetics.