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The value of blood derived DNA methylation signatures in advancing our understanding of Crohn's Disease pathogenesis.

Accepted version
Peer-reviewed

Type

Article

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Authors

Abstract

DNA methylation is one of the main epigenetic mechanisms, known to be operative in mammals. Extensive evidence has highlighted its pivotal role in several fundamental biological processes including organogenesis, X-chromosome inactivation and genomic imprinting (1). Although our understanding of how DNA methylation impacts on gene transcription and cellular function remains incomplete, it is clear that DNA methylation plays an important role in defining cell and tissue specific cellular function (2,3). Increasing evidence suggests that altered DNA methylation can contribute to either the development and/or persistence of many human diseases. Importantly, what makes epigenetic mechanisms a particularly attractive concept when it comes to investigating disease pathogenesis of modern, multi-factorial/complex diseases is their responsiveness to environmental factors (4).

Description

Keywords

32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Digestive Diseases, Human Genome, Genetics, 2.1 Biological and endogenous factors, 2 Aetiology, 1.1 Normal biological development and functioning, 1 Underpinning research, Generic health relevance

Journal Title

Translational Gastroenterology and Hepatology

Conference Name

Journal ISSN

2415-1289
2415-1289

Volume Title

4

Publisher

AME Publishing Company

Rights

All rights reserved