The value of blood derived DNA methylation signatures in advancing our understanding of Crohn's Disease pathogenesis.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
DNA methylation is one of the main epigenetic mechanisms, known to be operative in mammals. Extensive evidence has highlighted its pivotal role in several fundamental biological processes including organogenesis, X-chromosome inactivation and genomic imprinting (1). Although our understanding of how DNA methylation impacts on gene transcription and cellular function remains incomplete, it is clear that DNA methylation plays an important role in defining cell and tissue specific cellular function (2,3). Increasing evidence suggests that altered DNA methylation can contribute to either the development and/or persistence of many human diseases. Importantly, what makes epigenetic mechanisms a particularly attractive concept when it comes to investigating disease pathogenesis of modern, multi-factorial/complex diseases is their responsiveness to environmental factors (4).
Description
Keywords
Journal Title
Conference Name
Journal ISSN
2415-1289