A new approach to treating renal anaemia.
Nature reviews. Nephrology
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Maxwell, P. (2019). A new approach to treating renal anaemia.. Nature reviews. Nephrology, 15 (12), 731-732. https://doi.org/10.1038/s41581-019-0207-7
Erythropoiesis-stimulating agents (ESAs) are widely used to treat anaemia in patients with kidney disease. A potential alternative approach is to increase erythropoietin production using small-molecule inhibitors of prolyl hydroxylase domain (PHD) enzymes. Recent phase III trials of the PHD inhibitor roxadustat demonstrate similar efficacy and safety to ESAs.
Humans, Anemia, Isoquinolines, Glycine, Renal Dialysis
Wellcome Trust Senior Investigator Award Rosetrees Trust
External DOI: https://doi.org/10.1038/s41581-019-0207-7
This record's URL: https://www.repository.cam.ac.uk/handle/1810/298729
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