Macroautophagy/autophagy is a conserved degradation system that engulf s i ntracytoplasmic contents, including aggregated proteins and organelles , which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of aging have been reported to be associated with prog ressive ly compromised autophagy. D ysfunctional autophagy may contribute to age related diseases such as neurodegenerative disease, cancer, and metabolic syndrome in the elderly Therefore, restoration of impaired autophagy to normal may help to prevent age related disease and extend lifespan and longevit y. Therefore, this review aims to provide an overview of the mechanism s of autophagy machinery underlying cellular aging and the consequent disease Understanding the mechanisms of autophagy can provide potential information to aid therapeutic intervention s in age related diseases.