Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study.
Shipley, Martin J
Valencia-Hernández, Carlos A
Brunner, Eric J
European journal of epidemiology
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Araghi, M., Shipley, M. J., Wilkinson, I., McEniery, C., Valencia-Hernández, C. A., Kivimaki, M., Sabia, S., et al. (2019). Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study.. European journal of epidemiology https://doi.org/10.1007/s10654-019-00586-3
Aortic stiffness is associated with an increased risk of cardio- and cerebrovascular disease and mortality and may increase risk of dementia. The aim of the present study is to examine the association between arterial stiffness and cognitive decline in a large prospective cohort study with three repeated cognitive assessment over 7 years of follow-up. Aortic pulse wave velocity (PWV) was measured among 4,300 participants (mean±standard deviation age 65.1±5.2 years) in 2007-09 and categorized based on the tertiles: (lowest third: <7.41 m/s), (middle third: 7.41-8.91 m/s), and (highest third: >8.91 m/s). A battery of cognitive tests was administered to assess cognitive function in 2007-09, 2012-13, and 2015-16. Standardized global cognitive score (mean=0, SD=1) in highest third versus lowest third of PWV category was lower at baseline (-0.12, 95% CI -0.18, -0.06). Accelerated 7-year cognitive decline was observed among individuals with the highest PWV [difference in 7-year cognitive change for highest third vs. lowest third PWV: -0.06, 95% CI -0.11, -0.01, P <0.01]. Higher aortic stiffness was associated with faster cognitive decline. Clinicians may be able to use arterial stiffness severity as an indicator to administer prompt treatments to prevent or delay the onset of cognitive decline or dementia. Future studies need to determine whether early intervention of vascular stiffness is effective in delaying these outcomes.
British Heart Foundation (FS/12/8/29377)
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External DOI: https://doi.org/10.1007/s10654-019-00586-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/298882
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