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dc.contributor.authorAraghi, Marziehen
dc.contributor.authorShipley, Martin Jen
dc.contributor.authorWilkinson, Ianen
dc.contributor.authorMcEniery, Carmelen
dc.contributor.authorValencia-Hernández, Carlos Aen
dc.contributor.authorKivimaki, Mikaen
dc.contributor.authorSabia, Séverineen
dc.contributor.authorSingh-Manoux, Archanaen
dc.contributor.authorBrunner, Eric Jen
dc.date.accessioned2019-11-14T00:30:41Z
dc.date.available2019-11-14T00:30:41Z
dc.date.issued2020-09en
dc.identifier.issn0393-2990
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/298882
dc.description.abstractAortic stiffness is associated with an increased risk of cardio- and cerebrovascular disease and mortality and may increase risk of dementia. The aim of the present study is to examine the association between arterial stiffness and cognitive decline in a large prospective cohort study with three repeated cognitive assessment over 7 years of follow-up. Aortic pulse wave velocity (PWV) was measured among 4,300 participants (mean±standard deviation age 65.1±5.2 years) in 2007-09 and categorized based on the tertiles: (lowest third: <7.41 m/s), (middle third: 7.41-8.91 m/s), and (highest third: >8.91 m/s). A battery of cognitive tests was administered to assess cognitive function in 2007-09, 2012-13, and 2015-16. Standardized global cognitive score (mean=0, SD=1) in highest third versus lowest third of PWV category was lower at baseline (-0.12, 95% CI -0.18, -0.06). Accelerated 7-year cognitive decline was observed among individuals with the highest PWV [difference in 7-year cognitive change for highest third vs. lowest third PWV: -0.06, 95% CI -0.11, -0.01, P <0.01]. Higher aortic stiffness was associated with faster cognitive decline. Clinicians may be able to use arterial stiffness severity as an indicator to administer prompt treatments to prevent or delay the onset of cognitive decline or dementia. Future studies need to determine whether early intervention of vascular stiffness is effective in delaying these outcomes.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectArteriesen
dc.subjectHumansen
dc.subjectMemory Disordersen
dc.subjectSeverity of Illness Indexen
dc.subjectRisk Factorsen
dc.subjectCohort Studiesen
dc.subjectLongitudinal Studiesen
dc.subjectProspective Studiesen
dc.subjectHealth Behavioren
dc.subjectCognitionen
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectVascular Stiffnessen
dc.subjectPulse Wave Analysisen
dc.subjectCognitive Dysfunctionen
dc.titleAssociation of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study.en
dc.typeArticle
prism.endingPage869
prism.issueIdentifier9en
prism.publicationDate2020en
prism.publicationNameEuropean journal of epidemiologyen
prism.startingPage861
prism.volume35en
dc.identifier.doi10.17863/CAM.45938
dcterms.dateAccepted2019-11-13en
rioxxterms.versionofrecord10.1007/s10654-019-00586-3en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-09en
dc.contributor.orcidWilkinson, Ian [0000-0001-6598-9399]
dc.contributor.orcidMcEniery, Carmel [0000-0003-3636-0705]
dc.contributor.orcidSabia, Séverine [0000-0003-3109-9720]
dc.contributor.orcidSingh-Manoux, Archana [0000-0002-1244-5037]
dc.contributor.orcidBrunner, Eric J [0000-0002-0595-4474]
dc.identifier.eissn1573-7284
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (FS/12/8/29377)
cam.orpheus.successThu Jan 30 10:35:49 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-11-27


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