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dc.contributor.authorMuthui, Michelle K
dc.contributor.authorKamau, Alice
dc.contributor.authorBousema, Teun
dc.contributor.authorBlagborough, Andrew M
dc.contributor.authorBejon, Philip
dc.contributor.authorKapulu, Melissa C
dc.date.accessioned2019-11-14T00:30:44Z
dc.date.available2019-11-14T00:30:44Z
dc.date.issued2019
dc.identifier.issn1664-3224
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/298884
dc.description.abstractBackground: Malaria elimination remains a priority research agenda with the need for interventions that reduce and/or block malaria transmission from humans to mosquitoes. Transmission-blocking vaccines (TBVs) are in development, most of which target the transmission stage (i.e., gametocyte) antigens Pfs230 and Pfs48/45. For these interventions to be implemented, there is a need to understand the naturally acquired immunity to gametocytes. Several studies have measured the prevalence of immune responses to Pfs230 and Pfs48/45 in populations in malaria-endemic areas. Methods: We conducted a systematic review of studies carried out in African populations that measured the prevalence of immune responses to the gametocyte antigens Pfs230 and Pfs48/45. We assessed seroprevalence of antibody responses to the two antigens and investigated the effects of covariates such as age, transmission intensity/endemicity, season, and parasite prevalence on the prevalence of these antibody responses by meta-regression. Results: We identified 12 studies covering 23 sites for inclusion in the analysis. We found that the range of reported seroprevalence to Pfs230 and Pfs48/45 varied widely across studies, from 0 to 64% for Pfs48/45 and from 6 to 72% for Pfs230. We also found a modest association between increased age and increased seroprevalence to Pfs230: adults were associated with higher seroprevalence estimates in comparison to children (β coefficient 0.21, 95% CI: 0.05–0.38, p = 0.042). Methodological factors were the most significant contributors to heterogeneity between studies which prevented calculation of pooled prevalence estimates. Conclusions: Naturally acquired sexual stage immunity, as detected by antibodies to Pfs230 and Pfs48/45, was present in most studies analyzed. Significant between-study heterogeneity was seen, and methodological factors were a major contributor to this, and prevented further analysis of epidemiological and biological factors. This demonstrates a need for standardized protocols for conducting and reporting seroepidemiological analyses.
dc.description.sponsorshipMM and AK are funded via IDeAL Ph.D. Studentships awarded by the KEMRI-Wellcome Trust Research Programme through funding from the DELTAS Africa programme via the Wellcome Trust (107769). TB was supported by a grant from The Netherlands Organization for Scientific Research (Vidi fellowship; NWO Project 016.158.306). AB was funded by the MRC (New Investigator Research Grant; award number MR/N00227X/1) and the University of Cambridge JRG. PB and MK were supported by a Wellcome Trust grant (107499).
dc.publisherFrontiers Media
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleImmune Responses to Gametocyte Antigens in a Malaria Endemic Population—The African falciparum Context: A Systematic Review and Meta-Analysis
dc.typeArticle
prism.number2480
prism.publicationNameFrontiers in Immunology
prism.volume10
dc.identifier.doi10.17863/CAM.45940
dcterms.dateAccepted2019-10-04
rioxxterms.versionofrecord10.3389/fimmu.2019.02480
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-10-04
dc.identifier.eissn1664-3224
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/N00227X/1)
cam.issuedOnline2019-10-22


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International