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dc.contributor.authorPetry, Cliveen
dc.contributor.authorOng, Kennethen
dc.contributor.authorHughes, Ieuanen
dc.contributor.authorAcerini, Carlo Len
dc.contributor.authorDunger, Daviden
dc.date.accessioned2019-11-15T00:30:27Z
dc.date.available2019-11-15T00:30:27Z
dc.date.issued2019-11-19en
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/298891
dc.description.abstractPrevious studies have suggested that in the first decade of this century the incidence of gestational diabetes (GDM) in pregnancy rose worldwide. In the Cambridge Baby Growth Study cohort we observed that this temporal trend was associated with an index of multiple deprivation and reductions in indices of insulin secretion. Deprivation level was not directly associated with GDM, suggesting that the temporal trend may relate more to other factors linked to it, such as dietary composition. In this study we investigated temporal trends in perceived food intake frequencies, derived from a qualitative, short questionnaire, in 895 pregnant CBGS recruits. A number of food frequency ranks showed both temporal trends and associations with GDM, but of note is the frequency of egg consumption (negative temporal trend p=0.03, slope=-6.2 ranks/year; negative association with GDM p=3.0x10-8, slope=-0.002 increased risk/rank) as it was also positively associated with the insulin disposition index (p=1.17x10-3, slope=0.42 ranks.L/mmol). These results are consistent with a potential protective effect of factors related to the frequency of egg consumption in pregnancy. Such factors may have contributed to the observed temporal trend in GDM risk but the overall detectable effect appears to have been small.
dc.description.sponsorshipThis work was funded by the Medical Research Council (grant numbers G1001995, 7500001180); European Union Framework 5 (grant number QLK4-1999-01422); the Mothercare Charitable Foundation (grant number RG54608); Newlife – The Charity for Disabled Children (grant number 07/20); the World Cancer Research Fund International (grant number 2004/03); and the National Institute for Health Research Cambridge Biomedical Research Centre. K.K.O. is supported by the Medical Research Council (Unit Programme number: MC_UU_12015/2).
dc.format.mediumElectronicen
dc.languageengen
dc.publisherMDPI AG
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectHumansen
dc.subjectDiabetes, Gestationalen
dc.subjectInsulinen
dc.subjectBlood Glucoseen
dc.subjectDieten
dc.subjectIncidenceen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectLongitudinal Studiesen
dc.subjectProspective Studiesen
dc.subjectFeeding Behavioren
dc.subjectNutritional Statusen
dc.subjectPregnancyen
dc.subjectEatingen
dc.subjectTime Factorsen
dc.subjectEggsen
dc.subjectAdulten
dc.subjectEnglanden
dc.subjectFemaleen
dc.subjectMaternal Nutritional Physiological Phenomenaen
dc.subjectProtective Factorsen
dc.subjectBiomarkersen
dc.titleTemporal Trends in Maternal Food Intake Frequencies and Associations with Gestational Diabetes: The Cambridge Baby Growth Study.en
dc.typeArticle
prism.issueIdentifier11en
prism.publicationDate2019en
prism.publicationNameNutrientsen
prism.volume11en
dc.identifier.doi10.17863/CAM.45948
dcterms.dateAccepted2019-11-13en
rioxxterms.versionofrecord10.3390/nu11112822en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2019-11-19en
dc.contributor.orcidPetry, Clive [0000-0002-6642-9825]
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.contributor.orcidDunger, David [0000-0002-2566-9304]
dc.identifier.eissn2072-6643
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idNational Institute for Health Research (NIHR) (unknown)
pubs.funder-project-idMRC (MC_UU_12015/2)
pubs.funder-project-idMRC (G1001995)
pubs.funder-project-idMRC (G0500733)
pubs.funder-project-idMRC (G0600717)
rioxxterms.freetoread.startdate2022-11-14


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