Metabolism and cancer: the future is now.
British journal of cancer
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Frezza, C. (2020). Metabolism and cancer: the future is now.. British journal of cancer, 122 (2), 133-135. https://doi.org/10.1038/s41416-019-0667-3
Introduction If we look back ten years ago, the main questions in the field of cancer metabolism were whether and why cancer cells exhibited the so-called “Warburg effect”, a metabolic switch from oxidative to glycolytic metabolism. For years it was unclear why fast proliferating cancer cells would undergo this metabolic switch considered by many an inefficient use of nutrients (reviewed in PMID: 18393789). This fervid discussion was epitomised by a landmark review from Vander Heiden and colleagues, who proposed that the “Warburg effect” should not be viewed solely from the point of view of energy generation, but, instead, should be considered as a mean to synthesise anabolic molecules (PMID: 19460998). This change in perspective, almost a new Weltanschauung for the field, fostered new lines of enquiries to determine how cancer cells fulfil their biosynthetic needs, and connected the “Warburg effect” to nucleotide, lipids, and protein metabolism. Nowadays, we are facing another revolution. After years spent charting the many metabolic pathways explored by cancer cells to retrieve nutrients for growth and proliferation, the community has realised that the metabolic layer is at the interface between many other cellular processes in the cells and that it is more heterogeneous and subject to external cues than anticipated. In this special issue of the British Journal of Cancer, we present primary research papers and reviews that investigate poorly explored areas of cancer metabolism and the many processes to which dysregulated metabolism contributes.
Humans, Neoplasms, Cell Transformation, Neoplastic
External DOI: https://doi.org/10.1038/s41416-019-0667-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/299048
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