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Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Hyvärinen, Tanja 
Hyysalo, Anu 
Kapucu, Fikret Emre 
Aarnos, Laura 
Vinogradov, Andrey 

Abstract

Human pluripotent stem cell (hPSC)-derived neurons provide exciting opportunities for in vitro modeling of neurological diseases and for advancing drug development and neurotoxicological studies. However, generating electrophysiologically mature neuronal networks from hPSCs has been challenging. Here, we report the differentiation of functionally active hPSC-derived cortical networks on defined laminin-521 substrate. We apply microelectrode array (MEA) measurements to assess network events and compare the activity development of hPSC-derived networks to that of widely used rat embryonic cortical cultures. In both of these networks, activity developed through a similar sequence of stages and time frames; however, the hPSC-derived networks showed unique patterns of bursting activity. The hPSC-derived networks developed synchronous activity, which involved glutamatergic and GABAergic inputs, recapitulating the classical cortical activity also observed in rodent counterparts. Principal component analysis (PCA) based on spike rates, network synchronization and burst features revealed the segregation of hPSC-derived and rat network recordings into different clusters, reflecting the species-specific and maturation state differences between the two networks. Overall, hPSC-derived neural cultures produced with a defined protocol generate cortical type network activity, which validates their applicability as a human-specific model for pharmacological studies and modeling network dysfunctions.

Description

Keywords

Animals, Cell Culture Techniques, Cell Differentiation, Cell Line, Cerebellar Cortex, Glutamic Acid, Humans, Laminin, Microelectrodes, Nerve Net, Neural Stem Cells, Neurons, Pluripotent Stem Cells, Rats, Rats, Wistar, gamma-Aminobutyric Acid

Journal Title

Sci Rep

Conference Name

Journal ISSN

2045-2322
2045-2322

Volume Title

9

Publisher

Springer Science and Business Media LLC
Sponsorship
Finnish sources