Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis.
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Authors
Heslin, Margaret
Donoghue, Kim
Lomas, Ben
Onyejiaka, Adanna
Croudace, Tim
Fearon, Paul
Doody, Gillian A
Morgan, Craig
Publication Date
2020-07Journal Title
Psychological medicine
ISSN
0033-2917
Publisher
Cambridge University Press
Volume
50
Issue
9
Pages
1452-1462
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Dazzan, P., Lappin, J. M., Heslin, M., Donoghue, K., Lomas, B., Reininghaus, U., Onyejiaka, A., et al. (2020). Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis.. Psychological medicine, 50 (9), 1452-1462. https://doi.org/10.1017/s0033291719001399
Abstract
BACKGROUND: To determine the baseline individual characteristics that predicted symptom recovery and functional recovery at 10-years following the first episode of psychosis. METHODS: AESOP-10 is a 10-year follow up of an epidemiological, naturalistic population-based cohort of individuals recruited at the time of their first episode of psychosis in two areas in the UK (South East London and Nottingham). Detailed information on demographic, clinical, and social factors was examined to identify which factors predicted symptom and functional remission and recovery over 10-year follow-up. The study included 557 individuals with a first episode psychosis. The main study outcomes were symptom recovery and functional recovery at 10-year follow-up. RESULTS: At 10 years, 46.2% (n = 140 of 303) of patients achieved symptom recovery and 40.9% (n = 117) achieved functional recovery. The strongest predictor of symptom recovery at 10 years was symptom remission at 12 weeks (adj OR 4.47; CI 2.60-7.67); followed by a diagnosis of depression with psychotic symptoms (adj OR 2.68; CI 1.02-7.05). Symptom remission at 12 weeks was also a strong predictor of functional recovery at 10 years (adj OR 2.75; CI 1.23-6.11), together with being from Nottingham study centre (adj OR 3.23; CI 1.25-8.30) and having a diagnosis of mania (adj OR 8.17; CI 1.61-41.42). CONCLUSIONS: Symptom remission at 12 weeks is an important predictor of both symptom and functional recovery at 10 years, with implications for illness management. The concepts of clinical and functional recovery overlap but should be considered separately.
Sponsorship
This work was supported by UK Medical Research
Council (ref: G0500817) and the Department of Health via the National
Institute for Health Research (NIHR) Biomedical Research Centre at South
London and Maudsley Foundation Trust (SLaM) and King’s College
London
Identifiers
External DOI: https://doi.org/10.1017/s0033291719001399
This record's URL: https://www.repository.cam.ac.uk/handle/1810/299201