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dc.contributor.authorMelvin, Audreyen
dc.contributor.authorLacerda, Een
dc.contributor.authorDockrell, HMen
dc.contributor.authorO'Rahilly, Stephenen
dc.contributor.authorNacul, Len
dc.date.accessioned2019-11-27T00:32:26Z
dc.date.available2019-11-27T00:32:26Z
dc.date.issued2019-12-04en
dc.identifier.issn1479-5876
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/299333
dc.description.abstractBackground: Myalgic encephalomyelitis/Chronic fatigue syndrome (ME/CFS) is a debilitating condition characterised by fatigue and post-exertional malaise. Its pathogenesis is poorly understood. GDF15 is a circulating protein secreted by cells in response to a variety of stressors. The receptor for GDF15 is expressed in the brain, where its activation results in a range of responses. Among the conditions in which circulating GDF15 levels are highly elevated are mitochondrial disorders, where early skeletal muscle fatigue is a key symptom. We hypothesised that GDF15 may represent a marker of cellular stress in ME/CFS. Methods: GDF15 was measured in serum from patients with ME/CFS (n=150; 100 with mild/moderate and 50 with severe symptoms), “healthy volunteers” (n=150) and a cohort of patients with multiple sclerosis (n=50). Results: Circulating GDF15 remained stable in a subset of ME/CFS patients when sampled on two occasions ~7 months (IQR 6.7-8.8) apart, 720 pg/ml (95% CI=625-816) vs 670 pg/ml (95% CI=598-796), P=0.5. GDF15 levels were 491 pg/ml in controls (95% CI= 429-553), 546 pg/ml (95% CI= 478 to 614) in MS patients, 560 pg/ml (95% CI= 502 to 617) in mild/moderate ME/CFS patients and 602 pg/ml (95% CI=531 to 674) in severely affected ME/CFS patients. Accounting for potential confounders, severely affected ME/CFS patients had GDF15 concentrations that were significantly increased compared to healthy controls (P = 0.01). GDF15 levels were positively correlated (P=0.026) with fatigue scores in ME/CFS. Conclusions: Severe ME/CFS is associated with increased levels of GDF15, a circulating biomarker of cellular stress that appears which stable over several months.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherBioMed Central
dc.rightsAll rights reserved
dc.titleCirculating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2019en
prism.publicationNameJournal of translational medicineen
prism.startingPage409
prism.volume17en
dc.identifier.doi10.17863/CAM.46401
dcterms.dateAccepted2019-11-22en
rioxxterms.versionofrecord10.1186/s12967-019-02153-6en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-12-04en
dc.contributor.orcidMelvin, Audrey [0000-0002-9582-8454]
dc.contributor.orcidO'Rahilly, Stephen [0000-0003-2199-4449]
dc.identifier.eissn1479-5876
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12012/2)
pubs.funder-project-idWellcome Trust (214274/Z/18/Z)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMRC (MC_UU_12012/1)
pubs.funder-project-idMRC (MC_UU_12012/5)
pubs.funder-project-idMRC (MC_UU_00014/1)
pubs.funder-project-idMRC (MC_UU_00014/5)
cam.orpheus.successMon Jun 08 08:22:22 BST 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2022-11-26


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