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dc.contributor.authorGünesdogan, Ufuken
dc.contributor.authorSurani, Azimen
dc.date.accessioned2019-11-28T00:31:13Z
dc.date.available2019-11-28T00:31:13Z
dc.date.issued2016-01en
dc.identifier.issn0070-2153
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/299385
dc.description.abstractDuring mammalian embryonic development, the trophectoderm and primitive endoderm give rise to extraembryonic tissues, while the epiblast differentiates into all somatic lineages and the germline. Remarkably, only a few classes of signaling pathways induce the differentiation of these progenitor cells into diverse lineages. Accordingly, the functional outcome of a particular signal depends on the developmental competence of the target cells. Thus, developmental competence can be defined as the ability of a cell to integrate intrinsic and extrinsic cues to execute a specific developmental program toward a specific cell fate. Downstream of signaling, there is the combinatorial activity of transcription factors and their cofactors, which is modulated by the chromatin state of the target cells. Here, we discuss the concept of developmental competence, and the factors that regulate this state with reference to the specification of mammalian primordial germ cells.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAll rights reserved
dc.subjectGerm Cellsen
dc.subjectGerm Layersen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectSignal Transductionen
dc.subjectCell Differentiationen
dc.subjectEpigenesis, Geneticen
dc.subjectGene Expression Regulation, Developmentalen
dc.subjectEmbryonic Stem Cellsen
dc.titleDevelopmental Competence for Primordial Germ Cell Fate.en
dc.typeArticle
prism.endingPage496
prism.publicationDate2016en
prism.publicationNameCurrent topics in developmental biologyen
prism.startingPage471
prism.volume117en
dc.identifier.doi10.17863/CAM.46454
rioxxterms.versionofrecord10.1016/bs.ctdb.2015.11.007en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-01en
dc.contributor.orcidGünesdogan, Ufuk [0000-0002-8658-8022]
dc.contributor.orcidSurani, Azim [0000-0002-8640-4318]
dc.identifier.eissn1557-8933
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idCancer Research UK (A14492)
rioxxterms.freetoread.startdate2017-01-31


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