Toward a Common Coordinate Framework for the Human Body.
Rood, Jennifer E
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Rood, J. E., Stuart, T., Ghazanfar, S., Biancalani, T., Fisher, E., Butler, A., Hupalowska, A., et al. (2019). Toward a Common Coordinate Framework for the Human Body.. Cell, 179 (7), 1455-1467. https://doi.org/10.1016/j.cell.2019.11.019
Understanding the genetic and molecular features of phenotypic heterogeneity across individuals is central to biology. As new technologies enable fine-grained spatially resolved molecular profiling, we need new computational approaches to integrate data from the same organ across different individuals into a consistent reference, and to construct maps of molecular and cellular organization at histological and anatomical scales. Here, we review previous efforts and discuss challenges involved in establishing such a Common Coordinate Framework, the underlying map of tissues and organs. We focus on strategies to handle anatomical variation across individuals and highlight the need for new technologies and analytical methods spanning multiple hierarchical scales of spatial resolution.
This publication is part of the Human Cell Atlas. We gratefully acknowledge Richard Conroy, Ajay Pillai, Zorina Galis, and Katy Borner for generous feedback and discussion. This work was supported by the Human Biomolecular Atlas Project (NIH 1OT2OD026673- 01), NIH New Innovator Award (1DP2HG009623- 01), the Chan Zuckerberg Initiative (HCA2-A-1708-02755) and an NSF Graduate Fellowship (DGE1342536; A.B.). AR was additionally supported by the NIH BRAIN Initiative, Howard Hughes Medical Institute, and the Klarman Cell Observatory. S.G. is supported by a Royal Society Newton International Fellowship (NIF\R1\181950; E.F. is supported by the Wellcome Trust Mathematical Genomics and Medicine PhD programme (WT/215183/Z/19/Z). J.C.M. acknowledges core support from EMBL and from Cancer Research UK (C9545/A29580).
Cancer Research UK (C14303/A17197)
Royal Society (NIF\R1\181950)
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External DOI: https://doi.org/10.1016/j.cell.2019.11.019
This record's URL: https://www.repository.cam.ac.uk/handle/1810/299422
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Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/