Toward a Common Coordinate Framework for the Human Body.
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Authors
Rood, Jennifer E
Stuart, Tim
Biancalani, Tommaso
Butler, Andrew
Hupalowska, Anna
Gaffney, Leslie
Mauck, William
Eraslan, Gökçen
Regev, Aviv
Satija, Rahul
Publication Date
2019-12Journal Title
Cell
ISSN
0092-8674
Publisher
Elsevier
Volume
179
Issue
7
Pages
1455-1467
Language
eng
Type
Article
This Version
AM
Physical Medium
Print
Metadata
Show full item recordCitation
Rood, J. E., Stuart, T., Ghazanfar, S., Biancalani, T., Fisher, E., Butler, A., Hupalowska, A., et al. (2019). Toward a Common Coordinate Framework for the Human Body.. Cell, 179 (7), 1455-1467. https://doi.org/10.1016/j.cell.2019.11.019
Abstract
Understanding the genetic and molecular features of phenotypic heterogeneity across individuals is central to biology. As new technologies enable fine-grained spatially resolved molecular profiling, we need new computational approaches to integrate data from the same organ across different individuals into a consistent reference, and to construct maps of molecular and cellular organization at histological and anatomical scales. Here, we review previous efforts and discuss challenges involved in establishing such a Common Coordinate Framework, the underlying map of tissues and organs. We focus on strategies to handle anatomical variation across individuals and highlight the need for new technologies and analytical methods spanning multiple hierarchical scales of spatial resolution.
Keywords
Humans, Diagnostic Imaging, Physical Examination, Reference Standards, Anatomic Variation
Sponsorship
This publication is part of the Human Cell Atlas. We gratefully acknowledge Richard Conroy, Ajay Pillai, Zorina Galis, and Katy Borner for generous feedback and discussion. This work was supported by the Human Biomolecular Atlas Project (NIH 1OT2OD026673- 01), NIH New Innovator Award (1DP2HG009623- 01), the Chan Zuckerberg Initiative (HCA2-A-1708-02755) and an NSF Graduate Fellowship (DGE1342536; A.B.). AR was additionally supported by the NIH BRAIN Initiative, Howard Hughes Medical Institute, and the Klarman Cell Observatory. S.G. is supported by a Royal Society Newton International Fellowship (NIF\R1\181950; E.F. is supported by the Wellcome Trust Mathematical Genomics and Medicine PhD programme (WT/215183/Z/19/Z). J.C.M. acknowledges core support from EMBL and from Cancer Research UK (C9545/A29580).
Funder references
Cancer Research UK (C14303_do not transfer)
Royal Society (NIF\R1\181950)
Identifiers
External DOI: https://doi.org/10.1016/j.cell.2019.11.019
This record's URL: https://www.repository.cam.ac.uk/handle/1810/299422
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/