Spindle orientation: a question of complex positioning.
Development (Cambridge, England)
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Bergstralh, D., Dawney, N. S., & St Johnston, D. (2017). Spindle orientation: a question of complex positioning.. Development (Cambridge, England), 144 (7), 1137-1145. https://doi.org/10.1242/dev.140764
The direction in which a cell divides is determined by the orientation of its mitotic spindle at metaphase. Spindle orientation is therefore important for a wide range of developmental processes, ranging from germline stem cell division to epithelial tissue homeostasis and regeneration. In multiple cell types in multiple animals, spindle orientation is controlled by a conserved biological machine that mediates a pulling force on astral microtubules. Restricting the localization of this machine to only specific regions of the cortex can thus determine how the mitotic spindle is oriented. As we review here, recent findings based on studies in tunicate, worm, fly and vertebrate cells have revealed that the mechanisms for mediating this restriction are surprisingly diverse.
Microtubules, Animals, Humans, GTP-Binding Protein alpha Subunits, Gi-Go, Cell Division, Cell Shape, Models, Biological, Spindle Apparatus
The Wellcome Trust
External DOI: https://doi.org/10.1242/dev.140764
This record's URL: https://www.repository.cam.ac.uk/handle/1810/299430
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