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dc.contributor.authorMazarello Paes, Veenaen
dc.contributor.authorBarrett, Jessicaen
dc.contributor.authorDunger, Daviden
dc.contributor.authorGevers, Evelien Fen
dc.contributor.authorTaylor-Robinson, David Cen
dc.contributor.authorViner, Russell Men
dc.contributor.authorStephenson, Terence Jen
dc.date.accessioned2019-11-30T00:30:15Z
dc.date.available2019-11-30T00:30:15Z
dc.date.issued2019-11-29en
dc.identifier.issn1399-543X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/299455
dc.description.abstractBackground/aims: Poor early glycaemic control in childhood onset type 1 diabetes (T1D) is associated with future risk of acute and chronic complications. Our aim was to identify the predictors of higher glycated hemoglobin (HbA1c) within 24 months of T1D diagnosis in children and adolescents. Methods: Mixed effects models with fractional polynomials were used to analyse longitudinal data of patients <19 years of age, followed from T1D diagnosis for up to 2 years, at three diabetes clinics in East London, UK. Results: A total of 2209 HbA1c observations were available for 356 patients (52.5% female; 64.4% non-white), followed from within 3 months of diagnosis during years 2005 to 2015, with a mean±SD of 6.2±2.5 HbA1c observations/participant. The mean age and HbA1c at diagnosis were 8.9±4.3 years and 10.7% ±4.3% (or expressed as mmol/mol HbA1c mean±SD 92.9±23.10 mmol/mol) respectively. Over the 2 years following T1D diagnosis, HbA1c levels were mostly above the National Institute for Health, Care and Excellence (NICE), UK recommendations of 7.5% (<58mmol/mol). Significant (p<0.05) predictors of poorer glycaemic control were: Age at diagnosis (12-18 years), higher HbA1c at baseline (>9.5% i.e. >80mmol/mol), clinic site, non-white ethnicity and period (pre-year 2011) of diagnosis. Additionally in univariable analyses, frequency of clinic visits, HbA1c at diagnosis and type of insulin treatment regimen showed association with poor glycaemic control (p<0.05). Conclusions: Major risk factors of poorer glycaemic control during 3-24 months following childhood onset T1D are: diagnosis prior to 2011, higher HbA1c levels at baseline, age at diagnosis, non-white ethnicity and clinic site.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAll rights reserved
dc.rights.uri
dc.titleFactors predicting poor glycaemic control in the first two years of childhood onset type 1 diabetes in a cohort from East London, UK: Analyses using mixed effects fractional polynomial models.en
dc.typeArticle
prism.publicationDate2019en
prism.publicationNamePediatric diabetesen
dc.identifier.doi10.17863/CAM.46524
dcterms.dateAccepted2019-11-14en
rioxxterms.versionofrecord10.1111/pedi.12950en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-11-29en
dc.contributor.orcidMazarello Paes, Veena [0000-0002-4283-6266]
dc.contributor.orcidBarrett, Jessica [0000-0003-1889-9803]
dc.contributor.orcidDunger, David [0000-0002-2566-9304]
dc.identifier.eissn1399-5448
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (unknown)
cam.orpheus.successThu Jan 30 10:34:21 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-11-29


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