Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children
Haapala, Eero A
Tarkka, Ina M
Barker, Alan R
Lakka, Timo A
Medicine & Science in Sports & Exercise
Wolters Kluwer Health
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Haapala, E. A., Wiklund, P., Lintu, N., Tompuri, T., Väistö, J., Finni, T., Tarkka, I. M., et al. (2020). Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children. Medicine & Science in Sports & Exercise, 52 (5), 1144-1152. https://doi.org/10.1249/mss.0000000000002216
Purpose: Few studies have investigated the independent and joint associations of cardiorespiratory fitness (CRF) and body fat percentage (BF%) with insulin resistance in children. We investigated the independent and combined associations of CRF and BF% with fasting glycaemia and insulin resistance and their interactions with physical activity (PA) and sedentary time among 452 children aged 6–8 years. Methods: We assessed CRF with a maximal cycle ergometer exercise test and used allometrically scaled maximal power output (Wmax) for lean body mass (LM1.13) and body mass (BM1) as measures of CRF. BF% and LM were measured by dual-energy X-ray absorptiometry, fasting glycaemia by fasting plasma glucose, and insulin resistance by fasting serum insulin and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). PA energy expenditure (PAEE), moderate-to-vigorous PA (MVPA), and sedentary time were assessed by combined movement and heart rate sensor. Results: Wmax/LM1.13 was not associated with glucose (β=0.065, 95% CI=-0.031 to 0.161), insulin (β=-0.079, 95% CI=-0.172 to 0.015), or HOMA-IR (β=-0.065, 95% CI=-0.161 to 0.030). Wmax/BM1 was inversely associated with insulin (β=-0.289, 95% CI=-0.377 to -0.200) and HOMA-IR (β=-0.269, 95% CI=-0.359 to -0.180). BF% was directly associated with insulin (β=0.409, 95% CI=0.325 to 0.494) and HOMA-IR (β=0.390, 95% CI=0.304 to 0.475). Higher Wmax/BM1, but not Wmax/LM1.13, was associated with lower insulin and HOMA-IR in children with higher BF%. Children with higher BF% and who had lower levels of MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR. Conclusion: Children with higher BF% together with less MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR. CRF appropriately controlled for body size and composition using LM was not related to insulin resistance among children.
SB was supported by UK Medical Research Council (MC_UU_12015/3) and the NIHR Biomedical Research Centre Cambridge [IS-BRC-1215-20014].
External DOI: https://doi.org/10.1249/mss.0000000000002216
This record's URL: https://www.repository.cam.ac.uk/handle/1810/299505
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