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The non-receptor tyrosine kinase ACK: regulatory mechanisms, signalling pathways and opportunities for attACKing cancer

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Fox, Millie 
Crafter, Claire 

Abstract

Activated Cdc42-associated kinase or ACK, is a non-receptor tyrosine kinase and an effector protein for the small G protein Cdc42. A substantial body of evidence has accumulated in the past few years heavily implicating ACK as a driver of oncogenic processes. Concomitantly, more is also being revealed regarding the signalling pathways involving ACK and molecular details of its modes of action. Some details are also available regarding the regulatory mechanisms of this kinase, including activation and regulation of its catalytic activity, however a full understanding of these aspects remains elusive. This review considers the current knowledge base concerning ACK and summarises efforts and future prospects to target ACK therapeutically in cancer.

Description

Keywords

ACK, protein-tyrosine kinases, small G proteins, Animals, Biological Transport, Cell Movement, Endocytosis, Enzyme Activation, Epigenesis, Genetic, Humans, Neoplasms, Phosphatidylinositol 3-Kinases, Protein-Tyrosine Kinases, Signal Transduction, Trans-Activators

Journal Title

Biochemical Society Transactions

Conference Name

Journal ISSN

0300-5127
1470-8752

Volume Title

47

Publisher

Portland Press, Ltd.

Rights

All rights reserved
Sponsorship
MRC (MR/N08354/1)
MRC