Breathe: Your Mitochondria Will Do the Rest… If They Are Healthy!
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Viscomi, Carlo
Zeviani, Massimo
Abstract
Dysfunctions of the mitochondrial electron transport chain cause severe, currently untreatable, diseases in humans. A new study by Jain et al. (2019) reports increased oxygen levels in the brain of complex-I-deficient mice. Reducing the O2 levels by hypoxia, carbon monoxide, or anemia, improved the clinical phenotype and prolonged the lifespan of the mouse model.
Description
Keywords
Animals, Brain, Humans, Hyperoxia, Leigh Disease, Mice, Mitochondria, Oxygen, Rest
Journal Title
Cell Metabolism
Conference Name
Journal ISSN
1550-4131
1932-7420
1932-7420
Volume Title
30
Publisher
Elsevier
Publisher DOI
Sponsorship
Medical Research Council (MC_UP_1002/1)
Medical Research Council (MC_UU_00015/8)
MRC (MC_UU_00015/8)
Medical Research Council (MC_UU_00015/7)
Medical Research Council (MC_UU_00015/8)
MRC (MC_UU_00015/8)
Medical Research Council (MC_UU_00015/7)
The authors’ work is supported by an MRC core grant to the Mitochondrial Biology Unit (MC_UU_00015/5).