Conservative and disruptive modes of adolescent change in human brain functional connectivity.
Vaghi, Matilde M
Patel, Ameera X
Dolan, Raymond J
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
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Váša, F., Romero-Garcia, R., Kitzbichler, M., Seidlitz, J., Whitaker, K., Vaghi, M. M., Kundu, P., et al. (2020). Conservative and disruptive modes of adolescent change in human brain functional connectivity.. Proceedings of the National Academy of Sciences of the United States of America, 117 (6), 3248-3253. https://doi.org/10.1073/pnas.1906144117
Adolescent changes in human brain function are not entirely understood. Here we used multi-echo functional magnetic resonance imaging (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of 330 cortical regions and 16 subcortical regions in 298 healthy adolescents scanned 520 times. Participants were aged 14-26 years, and were scanned on one to three occasions at least 6 months apart. We found two distinct modes of age-related change in FC: "conservative'' and "disruptive''. Conservative development was characteristic of primary cortex, which was strongly connected at 14 years and became even more connected in the period 14-26 years. Disruptive development was characteristic of association cortex and subcortical regions, where connectivity was re-modelled: connections that were weak at 14 years became stronger during adolescence, and connections that were strong at 14 years became weaker. These modes of development were quantified using the maturational index (MI), estimated as Spearman's correlation between edge-wise baseline FC (at 14 years, FC14) and adolescent change in FC (Delta FC), at each region. Disruptive systems (with negative MI) were activated by social cognition and autobiographical memory tasks in prior fMRI data, and significantly co-located with prior maps of aerobic glycolysis (AG), AG-related gene expression, post-natal cortical surface expansion, and adolescent shrinkage of cortical thickness. The presence of these two modes of development was robust to numerous sensitivity analyses. We conclude that human brain organisation is disrupted during adolescence by re-modeling of functional connectivity between association cortical and subcortical areas.
NSPN Consortium, Brain, Nerve Net, Humans, Magnetic Resonance Imaging, Adolescent Development, Head Movements, Adolescent, Adult, Female, Male, Young Adult, Connectome
Wellcome Trust (095844/Z/11/Z)
Guarantors of Brain (unknown)
MQ: Transforming Mental Health (MQ17-24 Vertes)
External DOI: https://doi.org/10.1073/pnas.1906144117
This record's URL: https://www.repository.cam.ac.uk/handle/1810/299681
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